The contribution of neuroimmune functioning and brain-derived neurotrophic factor (BDNF) to functional dysregulation in autism spectrum disorder was assessed in 29 patients under treatment in two specialized centers of Basilicata (Chiaromonte and Matera), Southern Italy, through analysis of serum levels of cytokines and BDNF. Elevated levels of the pro-inflammatory cytokine, including interleukin-1, interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-α and BDNF were observed, regardless of age and gender. Comparisons were made with age- and gender-related healthy controls. The present findings reinforce current notions regarding immunoexcitotoxic mechanisms contributing to the pathophysiology of autistic disorder.
Altered Cytokine and BDNF Levels in Autism Spectrum Disorder / Ricci, Serafino; Businaro, Rita; Ippoliti, Flora; LO VASCO, VINCENZA RITA; Massoni, Francesco; Onofri, E.; Troili, G. M.; Pontecorvi, V.; Morelli, M.; Rapp Ricciardi, M.; Archer, T.. - In: NEUROTOXICITY RESEARCH. - ISSN 1029-8428. - 24:4(2013), pp. 491-501. [10.1007/s12640-013-9393-4]
Altered Cytokine and BDNF Levels in Autism Spectrum Disorder
Vincenza Rita Lo Vasco;
2013
Abstract
The contribution of neuroimmune functioning and brain-derived neurotrophic factor (BDNF) to functional dysregulation in autism spectrum disorder was assessed in 29 patients under treatment in two specialized centers of Basilicata (Chiaromonte and Matera), Southern Italy, through analysis of serum levels of cytokines and BDNF. Elevated levels of the pro-inflammatory cytokine, including interleukin-1, interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-α and BDNF were observed, regardless of age and gender. Comparisons were made with age- and gender-related healthy controls. The present findings reinforce current notions regarding immunoexcitotoxic mechanisms contributing to the pathophysiology of autistic disorder.
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