Recently 5-fluorouracil 0.5% / salicylic acid 10% (5-FU/SA) topical solution has been included in the National Italian portfolio for lesion-directed treatment of grade I/II actinic keratosis (AKs) located on the face or scalp. To describe the utility of dermoscopy and RCM in treatment response monitoring of a series of AKs treated with 5-FU/SA as lesion-directed therapy. Consecutive patients were prospectively treated for a maximum of 12 weeks with 5-FU/SA for AKs located on the face or scalp. Clinical, dermoscopic and confocal images of one index AK were acquired at each visit and pre-specified criteria were evaluated. Clinical, dermoscopic and confocal responses were evaluated at last follow up visit. Fourteen patients were enrolled, of which five were treated for 12 weeks, 7 for 8 and 2 for 4 weeks. At a median follow up of 30 weeks, 64.3% (9/14) index AKs achieved complete clinical, 50% (7/14) complete dermoscopic and 42.9% (6/14) complete confocal clearance. Local skin reaction was mild and significantly decreased during therapy administration. Although the small number of cases, our study underlines the utility of both dermoscopy and in-vivo RCM in 5-FU/SA treatment response monitoring for AKs located on the face or scalp. This article is protected by copyright. All rights reserved.

Treatment monitoring of 5-Fluorouracil 0.5%/Salicylic Acid 10% lesion-directed therapy for actinic keratosis using dermoscopy and in-vivo reflectance confocal microscopy / Pampena, Riccardo; Condorelli, Alessandra; Cornacchia, Luigi; Guiducci, Laura; Raucci, Margherita; Benati, Elisa; Mirra, Marica; Peris, Ketty; Lai, Michela; Pellacani, Giovanni; Longo, Caterina. - In: DERMATOLOGIC THERAPY. - ISSN 1396-0296. - (2020), pp. e13744-N/A. [10.1111/dth.13744]

Treatment monitoring of 5-Fluorouracil 0.5%/Salicylic Acid 10% lesion-directed therapy for actinic keratosis using dermoscopy and in-vivo reflectance confocal microscopy

Pampena, Riccardo
;
Condorelli, Alessandra;Guiducci, Laura;Lai, Michela;Pellacani, Giovanni;Longo, Caterina
2020

Abstract

Recently 5-fluorouracil 0.5% / salicylic acid 10% (5-FU/SA) topical solution has been included in the National Italian portfolio for lesion-directed treatment of grade I/II actinic keratosis (AKs) located on the face or scalp. To describe the utility of dermoscopy and RCM in treatment response monitoring of a series of AKs treated with 5-FU/SA as lesion-directed therapy. Consecutive patients were prospectively treated for a maximum of 12 weeks with 5-FU/SA for AKs located on the face or scalp. Clinical, dermoscopic and confocal images of one index AK were acquired at each visit and pre-specified criteria were evaluated. Clinical, dermoscopic and confocal responses were evaluated at last follow up visit. Fourteen patients were enrolled, of which five were treated for 12 weeks, 7 for 8 and 2 for 4 weeks. At a median follow up of 30 weeks, 64.3% (9/14) index AKs achieved complete clinical, 50% (7/14) complete dermoscopic and 42.9% (6/14) complete confocal clearance. Local skin reaction was mild and significantly decreased during therapy administration. Although the small number of cases, our study underlines the utility of both dermoscopy and in-vivo RCM in 5-FU/SA treatment response monitoring for AKs located on the face or scalp. This article is protected by copyright. All rights reserved.
e13744
N/A
Treatment monitoring of 5-Fluorouracil 0.5%/Salicylic Acid 10% lesion-directed therapy for actinic keratosis using dermoscopy and in-vivo reflectance confocal microscopy / Pampena, Riccardo; Condorelli, Alessandra; Cornacchia, Luigi; Guiducci, Laura; Raucci, Margherita; Benati, Elisa; Mirra, Marica; Peris, Ketty; Lai, Michela; Pellacani, Giovanni; Longo, Caterina. - In: DERMATOLOGIC THERAPY. - ISSN 1396-0296. - (2020), pp. e13744-N/A. [10.1111/dth.13744]
Pampena, Riccardo; Condorelli, Alessandra; Cornacchia, Luigi; Guiducci, Laura; Raucci, Margherita; Benati, Elisa; Mirra, Marica; Peris, Ketty; Lai, Michela; Pellacani, Giovanni; Longo, Caterina
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1203506
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