Drug-induced nephrolithiasis is a rare condition in children. The involved drugs may be divided into two different categories according to the mechanism involved in calculi formation. The first one includes poorly soluble drugs that favor the crystallization and calculi formation. The second category includes drugs that enhance calculi formation through their metabolic effects. The diagnosis of these specific calculi depends on a detailed medical history, associated comorbidities and the patient's history of drug consumption. There are several risk factors associated with drug-induced stones, such as high dose of consumed drugs and long duration of treatment. Moreover, there are some specific risk factors, including urinary pH and the amount of fluid consumed by children. There are limited data regarding pediatric lithogenic drugs, and hence, our aim was to perform a comprehensive review of the literature to summarize these drugs and identify the possible mechanisms involved in calculi formation and discuss the management and preventive measures for these calculi.

Drug-Induced Urolithiasis in Pediatric Patients / Sighinolfi, Maria Chiara; Eissa, Ahmed; Bevilacqua, Luigi; Zoeir, Ahmed; Ciarlariello, Silvia; Morini, Elena; Puliatti, Stefano; Durante, Viviana; Ceccarelli, Pier Luca; Micali, Salvatore; Bianchi, Giampaolo; Rocco, Bernardo. - In: PAEDIATRIC DRUGS. - ISSN 1174-5878. - 21:5(2019), pp. 323-344. [10.1007/s40272-019-00355-5]

Drug-Induced Urolithiasis in Pediatric Patients

Sighinolfi, Maria Chiara;Bevilacqua, Luigi;Ciarlariello, Silvia;Morini, Elena;Puliatti, Stefano;Ceccarelli, Pier Luca;Micali, Salvatore;Rocco, Bernardo
2019

Abstract

Drug-induced nephrolithiasis is a rare condition in children. The involved drugs may be divided into two different categories according to the mechanism involved in calculi formation. The first one includes poorly soluble drugs that favor the crystallization and calculi formation. The second category includes drugs that enhance calculi formation through their metabolic effects. The diagnosis of these specific calculi depends on a detailed medical history, associated comorbidities and the patient's history of drug consumption. There are several risk factors associated with drug-induced stones, such as high dose of consumed drugs and long duration of treatment. Moreover, there are some specific risk factors, including urinary pH and the amount of fluid consumed by children. There are limited data regarding pediatric lithogenic drugs, and hence, our aim was to perform a comprehensive review of the literature to summarize these drugs and identify the possible mechanisms involved in calculi formation and discuss the management and preventive measures for these calculi.
20-set-2019
21
5
323
344
Drug-Induced Urolithiasis in Pediatric Patients / Sighinolfi, Maria Chiara; Eissa, Ahmed; Bevilacqua, Luigi; Zoeir, Ahmed; Ciarlariello, Silvia; Morini, Elena; Puliatti, Stefano; Durante, Viviana; Ceccarelli, Pier Luca; Micali, Salvatore; Bianchi, Giampaolo; Rocco, Bernardo. - In: PAEDIATRIC DRUGS. - ISSN 1174-5878. - 21:5(2019), pp. 323-344. [10.1007/s40272-019-00355-5]
Sighinolfi, Maria Chiara; Eissa, Ahmed; Bevilacqua, Luigi; Zoeir, Ahmed; Ciarlariello, Silvia; Morini, Elena; Puliatti, Stefano; Durante, Viviana; Ceccarelli, Pier Luca; Micali, Salvatore; Bianchi, Giampaolo; Rocco, Bernardo
File in questo prodotto:
File Dimensione Formato  
145 sighinolfi2019 (1).pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 841.82 kB
Formato Adobe PDF
841.82 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1198937
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact