We present an electrical model for the high frequency impedance spectroscopy (HFIS) response of nanoelectrodes to CCMV capsids and full virus biomolecules. The virus electrical and geometrical parameters are extracted from available atomistic descriptions. Simulations of the response at a realistic HFIS CMOS platform suggest that the frequency of optimum sensitivity is within reach of existing designs. Furthermore, they shed light on the role of virus charge and ionic strength on the expected signal. The detection of single viruses could be possible with decananometer scale electrodes operated in optimal conditions and low-noise readout circuitry. © 2017 IEEE.
Modeling and Simulation of Small CCMV Virus Detection by means of High Frequency Impedance Spectroscopy at Nanoelectrodes / Cossettini, Andrea; Dalla Longa, Matteo; Scarbolo, Paolo; Selmi, Luca. - In: PROCEEDINGS OF THE ... IEEE CONFERENCE ON NANOTECHNOLOGY. - ISSN 1944-9399. - ELETTRONICO. - (2017), pp. 416-419. (Intervento presentato al convegno 17th IEEE International Conference on Nanotechnology, NANO 2017 tenutosi a Pittsburgh, USA nel 25 July 2017 through 28 July 2017) [10.1109/NANO.2017.8117367].
Modeling and Simulation of Small CCMV Virus Detection by means of High Frequency Impedance Spectroscopy at Nanoelectrodes
SELMI, Luca
2017
Abstract
We present an electrical model for the high frequency impedance spectroscopy (HFIS) response of nanoelectrodes to CCMV capsids and full virus biomolecules. The virus electrical and geometrical parameters are extracted from available atomistic descriptions. Simulations of the response at a realistic HFIS CMOS platform suggest that the frequency of optimum sensitivity is within reach of existing designs. Furthermore, they shed light on the role of virus charge and ionic strength on the expected signal. The detection of single viruses could be possible with decananometer scale electrodes operated in optimal conditions and low-noise readout circuitry. © 2017 IEEE.
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