Objective: To evaluate whether pretreatment with metformin improves FSH- induced ovulation in women with clomiphene-resistant polycystic ovary syndrome (PCOS). Design: Randomized prospective trial. Setting: Department of Obstetrics and Gynecology, University of Siena. Patient(s): Twenty women with clomiphene citrate-resistant PCOS. Intervention(s): The women were divided randomly into groups A and B (10 subjects each). Group B received 1,500 mg of metformin for at least a month before a single cycle of FSH stimulation. Group A underwent two cycles of FSH stimulation and then received metformin for a month before undergoing a third cycle. Main Outcome Measure(s): The number of FSH ampules, days of treatment, E 2 level on the day of hCG, number of follicles >15 mm, number of hyperstimulation, and the number of cycles with hCG withheld. Result(s): The number of follicles >15 mm in diameter on the day of hCG administration was significantly lower in cycles performed after metformin treatment. The percentage of cycles with hCG withheld because of excessive follicular development was significantly lower in cycles treated with metformin. Plasma levels of E 2 were significantly higher in cycles treated with FSH alone than in those treated with FSH and metformin. Conclusion(s): By reducing hyperinsulinism, metformin determines a reduction in intraovarian androgens. This leads to a reduction in E 2 levels and favors orderly follicular growth in response to exogenous gonadotropins.

Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome / De Leo, Vincenzo; Marca, Antonio La; Ditto, Antonino; Morgante, Giuseppe; Cianci, Antonio. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 72:2(1999), pp. 282-285. [10.1016/S0015-0282(99)00208-3]

Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome

Marca, Antonio La;Cianci, Antonio
1999

Abstract

Objective: To evaluate whether pretreatment with metformin improves FSH- induced ovulation in women with clomiphene-resistant polycystic ovary syndrome (PCOS). Design: Randomized prospective trial. Setting: Department of Obstetrics and Gynecology, University of Siena. Patient(s): Twenty women with clomiphene citrate-resistant PCOS. Intervention(s): The women were divided randomly into groups A and B (10 subjects each). Group B received 1,500 mg of metformin for at least a month before a single cycle of FSH stimulation. Group A underwent two cycles of FSH stimulation and then received metformin for a month before undergoing a third cycle. Main Outcome Measure(s): The number of FSH ampules, days of treatment, E 2 level on the day of hCG, number of follicles >15 mm, number of hyperstimulation, and the number of cycles with hCG withheld. Result(s): The number of follicles >15 mm in diameter on the day of hCG administration was significantly lower in cycles performed after metformin treatment. The percentage of cycles with hCG withheld because of excessive follicular development was significantly lower in cycles treated with metformin. Plasma levels of E 2 were significantly higher in cycles treated with FSH alone than in those treated with FSH and metformin. Conclusion(s): By reducing hyperinsulinism, metformin determines a reduction in intraovarian androgens. This leads to a reduction in E 2 levels and favors orderly follicular growth in response to exogenous gonadotropins.
1999
72
2
282
285
Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome / De Leo, Vincenzo; Marca, Antonio La; Ditto, Antonino; Morgante, Giuseppe; Cianci, Antonio. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 72:2(1999), pp. 282-285. [10.1016/S0015-0282(99)00208-3]
De Leo, Vincenzo; Marca, Antonio La; Ditto, Antonino; Morgante, Giuseppe; Cianci, Antonio
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1158913
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 226
  • ???jsp.display-item.citation.isi??? 171
social impact