After the first successful pregnancy in a liver transplant recipient in 1978, much evidence has accumulated on the course, outcomes and management strategies of pregnancy following liver transplantation. Generally, liver transplantation restores sexual function and fertility as early as a few months after transplant. Considering that one third of all liver transplant recipients are women, that approximately one-third of them are of reproductive age (18–49 years), and that 15% of female liver transplant recipients are paediatric patients who have a >70% probability of reaching reproductive age, the issue of pregnancy after liver transplantation is rather relevant, and obstetricians, paediatricians, and transplant hepatologists ever more frequently encounter such patients. Pregnancy outcomes for both the mother and infant in liver transplant recipients are generally good, but there is an increased incidence of preterm delivery, hypertension/preeclampsia, foetal growth restriction, and gestational diabetes, which, by definition, render pregnancy in liver transplant recipients a high-risk one. In contrast, the risk of congenital anomalies and the live birth rate are comparable to those of the general population. Currently there are still no robust guidelines on the management of pregnancies after liver transplantation. The aim of this position paper is to review the available evidence on pregnancy in liver transplant recipients and to provide national Italian recommendations for clinicians caring for these patients.

AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the Liver (AISF) / Alisi, Anna; Balsano, Clara; Bernabucci, Veronica; Berzigotti, Annalisa; Brunetto, Maurizia; Bugianesi, Elisabetta; Burra, Patrizia; Calvaruso, Vincenza; Cariani, Elisabetta; Coco, Barbara; Colle, Isabelle; Critelli, Rosina; De Martin, Eleonora; Del Buono, Mariagrazia; Fabregat, Isabel; Faillaci, Francesca; Fattovich, Giovanna; Floreani, Annarosa; Garcia-Tsao, Guadalupe; Housset, Chantal; Karampatou, Aimilia; Lei, Barbara; Mangia, Alessandra; Martinez-Chantar, Maria Luz; Milosa, Fabiola; Morisco, Filomena; Nasta, Paola; Ozben, Tomris; Pollicino, Teresa; Ponti, Maria Laura; Pontisso, Patrizia; Reeves, Helen; Rendina, Maria; Rodríguez-Castro, Kryssia Isabel; Sagnelli, Caterina; Sebastiani, Giada; Smedile, Antonella; Taliani, Gloria; Vandelli, Carmen; Vanni, Ester; Villa, Erica; Vukotic, Ranka; Zignego, Anna Linda; Rodríguez-Castro, Kryssia; GUARINO LO BIANCO, Maria; Morisco, Filomena; Villa, Erica; Mazzella, Giuseppe. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 48:8(2016), pp. 860-868. [10.1016/j.dld.2016.04.009]

AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the Liver (AISF)

Bernabucci, Veronica;Critelli, Rosina;FAILLACI, FRANCESCA;Garcia-Tsao, Guadalupe;Lei, Barbara;Milosa, Fabiola;TALIANI, GLORIA;Vandelli, Carmen;Villa, Erica;Vukotic, Ranka;GUARINO LO BIANCO, Maria;Villa, Erica;
2016

Abstract

After the first successful pregnancy in a liver transplant recipient in 1978, much evidence has accumulated on the course, outcomes and management strategies of pregnancy following liver transplantation. Generally, liver transplantation restores sexual function and fertility as early as a few months after transplant. Considering that one third of all liver transplant recipients are women, that approximately one-third of them are of reproductive age (18–49 years), and that 15% of female liver transplant recipients are paediatric patients who have a >70% probability of reaching reproductive age, the issue of pregnancy after liver transplantation is rather relevant, and obstetricians, paediatricians, and transplant hepatologists ever more frequently encounter such patients. Pregnancy outcomes for both the mother and infant in liver transplant recipients are generally good, but there is an increased incidence of preterm delivery, hypertension/preeclampsia, foetal growth restriction, and gestational diabetes, which, by definition, render pregnancy in liver transplant recipients a high-risk one. In contrast, the risk of congenital anomalies and the live birth rate are comparable to those of the general population. Currently there are still no robust guidelines on the management of pregnancies after liver transplantation. The aim of this position paper is to review the available evidence on pregnancy in liver transplant recipients and to provide national Italian recommendations for clinicians caring for these patients.
2016
20-mag-2016
48
8
860
868
AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the Liver (AISF) / Alisi, Anna; Balsano, Clara; Bernabucci, Veronica; Berzigotti, Annalisa; Brunetto, Maurizia; Bugianesi, Elisabetta; Burra, Patrizia; Calvaruso, Vincenza; Cariani, Elisabetta; Coco, Barbara; Colle, Isabelle; Critelli, Rosina; De Martin, Eleonora; Del Buono, Mariagrazia; Fabregat, Isabel; Faillaci, Francesca; Fattovich, Giovanna; Floreani, Annarosa; Garcia-Tsao, Guadalupe; Housset, Chantal; Karampatou, Aimilia; Lei, Barbara; Mangia, Alessandra; Martinez-Chantar, Maria Luz; Milosa, Fabiola; Morisco, Filomena; Nasta, Paola; Ozben, Tomris; Pollicino, Teresa; Ponti, Maria Laura; Pontisso, Patrizia; Reeves, Helen; Rendina, Maria; Rodríguez-Castro, Kryssia Isabel; Sagnelli, Caterina; Sebastiani, Giada; Smedile, Antonella; Taliani, Gloria; Vandelli, Carmen; Vanni, Ester; Villa, Erica; Vukotic, Ranka; Zignego, Anna Linda; Rodríguez-Castro, Kryssia; GUARINO LO BIANCO, Maria; Morisco, Filomena; Villa, Erica; Mazzella, Giuseppe. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 48:8(2016), pp. 860-868. [10.1016/j.dld.2016.04.009]
Alisi, Anna; Balsano, Clara; Bernabucci, Veronica; Berzigotti, Annalisa; Brunetto, Maurizia; Bugianesi, Elisabetta; Burra, Patrizia; Calvaruso, Vincen...espandi
File in questo prodotto:
File Dimensione Formato  
PIIS1590865816303917.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 998.08 kB
Formato Adobe PDF
998.08 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1154643
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 15
social impact