Background: The American Society of Echocardiography (ASE) and European Association of Echocardiography (EAE) recommend the use of quantitative estimation of left ventricular (LV) mass and defined partition values for mild, moderate, and severe hypertrophy. However, the prognostic implications associated with this categorization are unknown. Methods: In this observational cohort study of unselected adults undergoing echocardiography for any indication, LV hypertrophy was assessed using the ASE/EAE-recommended formula and measurement convention from LV linear dimensions indexed to body surface area. Mortality and incident hospitalizations for cardiovascular disease were the outcomes of this study. Results: Of 2,545 subjects (mean age, 61.9 ± 15.8 years; 56.3% women), 52.9% had normal LV mass, and 15.4% had mild, 12.1% moderate, and 19.6% severe LV hypertrophy. During a mean follow-up period of 2.5 ± 1.2 years, 121 deaths and 292 incident hospitalizations for cardiovascular disease occurred. In multivariate models including age, gender, LV ejection fraction, wall motion score index, significant valvular disease, and atrial fibrillation, the adjusted hazard ratios for death were 1.81 (95% confidence interval [CI], 1.03-3.20; P =.041) for mild, 2.31 (95% CI, 1.33-4.01; P =.003) for moderate, and 2.30 (95% CI, 1.39-3.79, P =.001) for severe LV hypertrophy. The adjusted hazard ratios for incident cardiovascular hospitalizations were 1.24 (95% CI, 0.84-1.82; P =.277) for mild, 2.02 (95% CI, 1.42-2.88; P =.0001) for moderate, and 2.38 (95% CI, 1.75-3.22, P <.0001) for severe LV hypertrophy. After adjustment for known risk predictors, there was a 1.3-fold risk for death and cardiovascular disease events per category of LV mass (P =.001). Conclusions: In a cohort study of unselected adult outpatients, the categorization of LV mass according to the ASE/EAE recommendations offered prognostic information independently of age, gender, and other known predictors. Copyright 2011 by the American Society of Echocardiography.

Prognostic impact of left ventricular mass severity according to the classification proposed by the American society of echocardiography/European association of echocardiography / Barbieri, Andrea; Bursi, Francesca; Mantovani, Francesca; Valenti, Chiara; Quaglia, Michele; Berti, ELENA MARIA; Marino, Massimiliano; Modena, Maria Grazia. - In: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY. - ISSN 0894-7317. - 24:12(2011), pp. 1383-1391. [10.1016/j.echo.2011.08.012]

Prognostic impact of left ventricular mass severity according to the classification proposed by the American society of echocardiography/European association of echocardiography

Bursi, Francesca;Mantovani, Francesca;Valenti, Chiara;Quaglia, Michele;BERTI, ELENA MARIA;Marino, Massimiliano;Modena, Maria Grazia
2011

Abstract

Background: The American Society of Echocardiography (ASE) and European Association of Echocardiography (EAE) recommend the use of quantitative estimation of left ventricular (LV) mass and defined partition values for mild, moderate, and severe hypertrophy. However, the prognostic implications associated with this categorization are unknown. Methods: In this observational cohort study of unselected adults undergoing echocardiography for any indication, LV hypertrophy was assessed using the ASE/EAE-recommended formula and measurement convention from LV linear dimensions indexed to body surface area. Mortality and incident hospitalizations for cardiovascular disease were the outcomes of this study. Results: Of 2,545 subjects (mean age, 61.9 ± 15.8 years; 56.3% women), 52.9% had normal LV mass, and 15.4% had mild, 12.1% moderate, and 19.6% severe LV hypertrophy. During a mean follow-up period of 2.5 ± 1.2 years, 121 deaths and 292 incident hospitalizations for cardiovascular disease occurred. In multivariate models including age, gender, LV ejection fraction, wall motion score index, significant valvular disease, and atrial fibrillation, the adjusted hazard ratios for death were 1.81 (95% confidence interval [CI], 1.03-3.20; P =.041) for mild, 2.31 (95% CI, 1.33-4.01; P =.003) for moderate, and 2.30 (95% CI, 1.39-3.79, P =.001) for severe LV hypertrophy. The adjusted hazard ratios for incident cardiovascular hospitalizations were 1.24 (95% CI, 0.84-1.82; P =.277) for mild, 2.02 (95% CI, 1.42-2.88; P =.0001) for moderate, and 2.38 (95% CI, 1.75-3.22, P <.0001) for severe LV hypertrophy. After adjustment for known risk predictors, there was a 1.3-fold risk for death and cardiovascular disease events per category of LV mass (P =.001). Conclusions: In a cohort study of unselected adult outpatients, the categorization of LV mass according to the ASE/EAE recommendations offered prognostic information independently of age, gender, and other known predictors. Copyright 2011 by the American Society of Echocardiography.
24
12
1383
1391
Prognostic impact of left ventricular mass severity according to the classification proposed by the American society of echocardiography/European association of echocardiography / Barbieri, Andrea; Bursi, Francesca; Mantovani, Francesca; Valenti, Chiara; Quaglia, Michele; Berti, ELENA MARIA; Marino, Massimiliano; Modena, Maria Grazia. - In: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY. - ISSN 0894-7317. - 24:12(2011), pp. 1383-1391. [10.1016/j.echo.2011.08.012]
Barbieri, Andrea; Bursi, Francesca; Mantovani, Francesca; Valenti, Chiara; Quaglia, Michele; Berti, ELENA MARIA; Marino, Massimiliano; Modena, Maria Grazia
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S089473171100633X-main.pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 218.19 kB
Formato Adobe PDF
218.19 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1148588
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 17
social impact