Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (<20 ng/ml), with very low vitamin D levels (<10 ng/ml) in 40 (44%) subjects. Only 15/49 (30.6%) patients of group B reached normal levels of 25-OH-vitD (≥30 ng/ml), whereas vitamin D deficiency persisted in 12/49 (24.5%) individuals. Parathormone levels inversely correlated with 25-OH-vitD (r = −0.3, p < 0.0001). Of interest, hypovitaminosis D was statistically associated with autoimmune thyroiditis (p = 0.008), while calcinosis was more frequently observed in patients of group A (p = 0.057). Moreover, we found significantly higher percentage of serum anticentromere antibodies in group B patients with 25-OH-vitD level ≥30 ng/ml (8/15 vs. 6/34; p = 0.017). In literature, hypovitaminosis D is very frequent in SSc patients. An association with disease duration, calcinosis, or severity of pulmonary involvement was occasionally recognized. Hypovitaminosis D is very frequent in SSc and severe in a relevant percentage of patients; furthermore, less than one third of supplemented subjects reached normal levels of 25-OH-vitD. The evaluation of 25-OH-vitD levels should be included in the routine clinical work-up of SSc. The above findings expand previous observations and may stimulate further investigations.
Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature / Giuggioli, Dilia; Colaci, Michele; Cassone, Giulia; Fallahi, P.; Lumetti, Federica; Spinella, Amelia; Campomori, Federica; Manfredi, Andreina Teresa; Manzini, Carlo Umberto; Antonelli, Andrea; Ferri, Clodoveo. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - 36:3(2017), pp. 583-590.
Data di pubblicazione: | 2017 |
Data di prima pubblicazione: | 9-gen-2017 |
Titolo: | Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature |
Autore/i: | Giuggioli, Dilia; Colaci, Michele; Cassone, Giulia; Fallahi, P.; Lumetti, Federica; Spinella, Amelia; Campomori, Federica; Manfredi, Andreina Teresa; Manzini, Carlo Umberto; Antonelli, Andrea; Ferri, Clodoveo |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10067-016-3535-z |
Rivista: | |
Volume: | 36 |
Fascicolo: | 3 |
Pagina iniziale: | 583 |
Pagina finale: | 590 |
Codice identificativo ISI: | WOS:000394989700012 |
Codice identificativo Scopus: | 2-s2.0-85008627044 |
Codice identificativo Pubmed: | 28070764 |
Citazione: | Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature / Giuggioli, Dilia; Colaci, Michele; Cassone, Giulia; Fallahi, P.; Lumetti, Federica; Spinella, Amelia; Campomori, Federica; Manfredi, Andreina Teresa; Manzini, Carlo Umberto; Antonelli, Andrea; Ferri, Clodoveo. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - 36:3(2017), pp. 583-590. |
Tipologia | Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | |
---|---|---|---|
Giuggioli et al SSc vitD Text FINAL.docx | Post-print dell'autore (bozza post referaggio) | Administrator Richiedi una copia |

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris