Purpose: Evolving therapies have improved the prognoses of patients with breast cancer; and currently, the number of long-term survivors is continuously increasing. However, these patients are at increased risk of developing a second cancer. Thus, late side effects are becoming an important issue. In this study, we aimed to investigate whether patient and tumor characteristics, and treatment type correlate with secondary tumor risk. Methods: This case-control study included 305 patients with a diagnosed second malignancy after almost 6 months after the diagnosis of primary breast cancer and 1,525 controls (ratio 1:5 of cases to controls) from a population-based cohort of 6,325 women. The control patients were randomly selected from the cohort and matched to the cases according to age at diagnosis, calendar period of diagnosis, disease stage, and time of follow-up. Results: BRCA1 or BRCA2 mutation, human epidermal growth factor receptor 2 (HER2)+ status, chemotherapy, and radiotherapy were related to increased risk of developing a second cancer, whereas hormonotherapy showed a protective effect. Chemotherapy, radiotherapy, and estrogenic receptor level <10% increased the risk of controlateral breast cancer. HER2+ status increased the risk of digestive system and thyroid tumors, while BRCA1 or BRCA2 mutation increased the risk of cancer in the genital system. Conclusion: Breast cancer survivors are exposed to an excess of risk of developing a second primary cancer. The development of excess of malignancies may be related either to patient and tumor characteristics, such as BRCA1 or BRCA2 mutation and HER2+ status, or to treatments factors.

Risk of second primary malignancy in breast cancer survivors: A nested population-based case-control study / Marcheselli, Raffaella; Marcheselli, Luigi; Cortesi, Laura; Bari, Alessia; Cirilli, Claudia; Pozzi, Samantha; Ferri, Paola; Napolitano, Martina; Federico, Massimo; Sacchi, Stefano. - In: JOURNAL OF BREAST CANCER. - ISSN 1738-6756. - ELETTRONICO. - 18:4(2015), pp. 378-385. [10.4048/jbc.2015.18.4.378]

Risk of second primary malignancy in breast cancer survivors: A nested population-based case-control study

MARCHESELLI, Raffaella;MARCHESELLI, Luigi;CORTESI, LAURA;BARI, Alessia;POZZI, Samantha;FERRI, Paola;Napolitano, Martina;FEDERICO, Massimo;SACCHI, Stefano
2015

Abstract

Purpose: Evolving therapies have improved the prognoses of patients with breast cancer; and currently, the number of long-term survivors is continuously increasing. However, these patients are at increased risk of developing a second cancer. Thus, late side effects are becoming an important issue. In this study, we aimed to investigate whether patient and tumor characteristics, and treatment type correlate with secondary tumor risk. Methods: This case-control study included 305 patients with a diagnosed second malignancy after almost 6 months after the diagnosis of primary breast cancer and 1,525 controls (ratio 1:5 of cases to controls) from a population-based cohort of 6,325 women. The control patients were randomly selected from the cohort and matched to the cases according to age at diagnosis, calendar period of diagnosis, disease stage, and time of follow-up. Results: BRCA1 or BRCA2 mutation, human epidermal growth factor receptor 2 (HER2)+ status, chemotherapy, and radiotherapy were related to increased risk of developing a second cancer, whereas hormonotherapy showed a protective effect. Chemotherapy, radiotherapy, and estrogenic receptor level <10% increased the risk of controlateral breast cancer. HER2+ status increased the risk of digestive system and thyroid tumors, while BRCA1 or BRCA2 mutation increased the risk of cancer in the genital system. Conclusion: Breast cancer survivors are exposed to an excess of risk of developing a second primary cancer. The development of excess of malignancies may be related either to patient and tumor characteristics, such as BRCA1 or BRCA2 mutation and HER2+ status, or to treatments factors.
2015
23-dic-2015
18
4
378
385
Risk of second primary malignancy in breast cancer survivors: A nested population-based case-control study / Marcheselli, Raffaella; Marcheselli, Luigi; Cortesi, Laura; Bari, Alessia; Cirilli, Claudia; Pozzi, Samantha; Ferri, Paola; Napolitano, Martina; Federico, Massimo; Sacchi, Stefano. - In: JOURNAL OF BREAST CANCER. - ISSN 1738-6756. - ELETTRONICO. - 18:4(2015), pp. 378-385. [10.4048/jbc.2015.18.4.378]
Marcheselli, Raffaella; Marcheselli, Luigi; Cortesi, Laura; Bari, Alessia; Cirilli, Claudia; Pozzi, Samantha; Ferri, Paola; Napolitano, Martina; Feder...espandi
File in questo prodotto:
File Dimensione Formato  
421 (ex763).pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 238.63 kB
Formato Adobe PDF
238.63 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1105551
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 26
social impact