We evaluated the reversing activity of ethacrynic acid in a B-CLL patient resistant to chlorambucil. The glutathione S-transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated. Ethacrynic acid, at pharmacological concentrations, partially reversed chlorambucil resistance and this result appeared related to the increased GST levels.
REVERSING OF CHLORAMBUCIL RESISTANCE BY ETHACRYNIC-ACID IN A B-CELL PATIENT / Petrini, M; Conte, Angela; Caracciolo, F; Sabbatini, Anna Maria Teresa; Grassi, B; Ronca, G.. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 85:(1993), pp. 409-410.
REVERSING OF CHLORAMBUCIL RESISTANCE BY ETHACRYNIC-ACID IN A B-CELL PATIENT
CONTE, Angela;SABBATINI, Anna Maria Teresa;
1993
Abstract
We evaluated the reversing activity of ethacrynic acid in a B-CLL patient resistant to chlorambucil. The glutathione S-transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated. Ethacrynic acid, at pharmacological concentrations, partially reversed chlorambucil resistance and this result appeared related to the increased GST levels.
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