Although the detection of BRAF p.V600E mutation by immunohistochemistry was clearly described in melanoma, discordant evidences were reported for the detection of p.V600K and p.V600R mutations. The aim of the study was to evaluate the efficacy of BRAFp.V600E, p.V600K, and p.V600R detection by immunohistochemistry in melanoma.
BRAFp.V600E, p.V600K, and p.V600R Mutations in Malignant Melanoma: Do They Also Differ in Immunohistochemical Assessment and Clinical Features? / Ponti, Giovanni; Tomasi, Aldo; Maiorana, Antonino; Ruini, Cristel; Maccaferri, Monia; Cesinaro, Anna M; Depenni, Roberta; Manni, Paola; Gelsomino, Fabio; Giusti, Francesca; Garagnani, Lorella; Pellacani, Giovanni. - In: APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY. - ISSN 1541-2016. - STAMPA. - 24:1(2016), pp. 30-34. [10.1097/PAI.0000000000000153]
BRAFp.V600E, p.V600K, and p.V600R Mutations in Malignant Melanoma: Do They Also Differ in Immunohistochemical Assessment and Clinical Features?
PONTI, Giovanni;TOMASI, Aldo;MAIORANA, Antonino;RUINI, CRISTEL;Maccaferri, Monia;DEPENNI, Roberta;MANNI, Paola;GELSOMINO, Fabio;GIUSTI, Francesca;GARAGNANI, Lorella;PELLACANI, Giovanni
2016-01-01
Abstract
Although the detection of BRAF p.V600E mutation by immunohistochemistry was clearly described in melanoma, discordant evidences were reported for the detection of p.V600K and p.V600R mutations. The aim of the study was to evaluate the efficacy of BRAFp.V600E, p.V600K, and p.V600R detection by immunohistochemistry in melanoma.
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