BACKGROUND AND PURPOSE: The aim of this study was to investigate the characteristic pattern of age-related cortical thinning in patients with Down Syndrome (DS), as assessed by MRI and automatic cortical thickness measurements. METHODS: Ninety-one non-demented subjects with DS (range 11-53 years) were examined using a 1.5 T scanner. MRI-based quantification of cortical thickness was performed using FreeSurfer software package., The Pearson product-moment correlation coefficient between age and mean cortical thickness was evaluated for all subjects participating in the study. RESULTS: A significant negative correlation between cortical thickness and age was found bilaterally in the frontal, temporal, parietal and cingulate gyrus. Specific investigation of cerebral lobes showed a more evident involvement of the frontal one, compared to others. Moreover, the age related reduction of cortical thickness appeared to be more significant and rapid in patients between 20 and 30 years of age. CONCLUSIONS: Our findings showed that Down Syndrome subjects are affected by a diffuse cortical thinning. The involvement of cortical structures can be observed at an earlier age than previous studies have reported.
|Data di pubblicazione:||2016|
|Titolo:||Age-Related Cortical Thickness Reduction in Non-Demented Down’s Syndrome Subjects|
|Autore/i:||Romano, Andrea; Cornia, Riccardo; Moraschi, Marta; Bozzao, Alessandro; Chiacchiararelli, Laura; Coppola, Valeria; Iani, Cristina; Stella, Giacomo; Albertini, Giorgio; Pierallini, Alberto|
|Digital Object Identifier (DOI):||10.1111/jon.12259.|
|Codice identificativo ISI:||WOS:000368012400013|
|Codice identificativo Scopus:||2-s2.0-84954028111|
|Codice identificativo Pubmed:||25996840|
|Citazione:||Age-Related Cortical Thickness Reduction in Non-Demented Down’s Syndrome Subjects / Romano, Andrea; Cornia, Riccardo; Moraschi, Marta; Bozzao, Alessandro; Chiacchiararelli, Laura; Coppola, Valeria; Iani, Cristina; Stella, Giacomo; Albertini, Giorgio; Pierallini, Alberto. - In: JOURNAL OF NEUROIMAGING. - ISSN 1051-2284. - ELETTRONICO. - 26(1)(2016), pp. 95-102.|
|Tipologia||Articolo su rivista|
File in questo prodotto:
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris