The C-X-C chemokine receptors 3 (CXCR3) and C-X-C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross-inhibit chemokine binding to CXCR4, CC chemokine receptors 2 (CCR2) and 5 (CCR5) heteromers. We investigated whether CXCR3 and CXCR4 can form heteromeric complexes and the binding characteristics of chemokines and small ligand compounds to these chemokine receptor heteromers.

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes / Watts, A. O; van Lipzig, M. M. H; Jaeger, W. C; Seeber, R. M; van Zwam, M; Vinet, Jonathan; van der Lee, M. M. C; Siderius, M; Zaman, G. J. R; Boddeke, H. W. G. M; Smit, M. J; Pfleger, K. D. G; Leurs, R; Vischer, H. F.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 168:(2013), pp. 1662-1674. [10.1111/bph.12064]

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes

VINET, JONATHAN;
2013

Abstract

The C-X-C chemokine receptors 3 (CXCR3) and C-X-C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross-inhibit chemokine binding to CXCR4, CC chemokine receptors 2 (CCR2) and 5 (CCR5) heteromers. We investigated whether CXCR3 and CXCR4 can form heteromeric complexes and the binding characteristics of chemokines and small ligand compounds to these chemokine receptor heteromers.
2013
168
1662
1674
Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes / Watts, A. O; van Lipzig, M. M. H; Jaeger, W. C; Seeber, R. M; van Zwam, M; Vinet, Jonathan; van der Lee, M. M. C; Siderius, M; Zaman, G. J. R; Boddeke, H. W. G. M; Smit, M. J; Pfleger, K. D. G; Leurs, R; Vischer, H. F.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 168:(2013), pp. 1662-1674. [10.1111/bph.12064]
Watts, A. O; van Lipzig, M. M. H; Jaeger, W. C; Seeber, R. M; van Zwam, M; Vinet, Jonathan; van der Lee, M. M. C; Siderius, M; Zaman, G. J. R; Boddeke, H. W. G. M; Smit, M. J; Pfleger, K. D. G; Leurs, R; Vischer, H. F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1074608
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