The C-X-C chemokine receptors 3 (CXCR3) and C-X-C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross-inhibit chemokine binding to CXCR4, CC chemokine receptors 2 (CCR2) and 5 (CCR5) heteromers. We investigated whether CXCR3 and CXCR4 can form heteromeric complexes and the binding characteristics of chemokines and small ligand compounds to these chemokine receptor heteromers.
Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes / Watts, A. O; van Lipzig, M. M. H; Jaeger, W. C; Seeber, R. M; van Zwam, M; Vinet, Jonathan; van der Lee, M. M. C; Siderius, M; Zaman, G. J. R; Boddeke, H. W. G. M; Smit, M. J; Pfleger, K. D. G; Leurs, R; Vischer, H. F.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 168:7(2013), pp. 1662-1674. [10.1111/bph.12064]
Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes
VINET, JONATHAN;
2013
Abstract
The C-X-C chemokine receptors 3 (CXCR3) and C-X-C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross-inhibit chemokine binding to CXCR4, CC chemokine receptors 2 (CCR2) and 5 (CCR5) heteromers. We investigated whether CXCR3 and CXCR4 can form heteromeric complexes and the binding characteristics of chemokines and small ligand compounds to these chemokine receptor heteromers.
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