Chemokine (C-X-C motif) ligand (CXCL)10 is involved in the pathogenesis of psoriasis. It has been demonstrated that chemokine (C-X-C motif) receptors (CXCR)3 and CXCL10 were detected in keratinocytes and the dermal infiltrate obtained from active psoriatic plaques and that successful treatment of active plaques decreased the expression of CXCL10. Elevated CXCL10 serum levels have been shown in patients with psoriasis, with a type 1 T helper cells immune predominance at the beginning of the disease, while a decline of this chemokine has been evidenced later, in long lasting psoriasis. Circulating CXCL10 is significantly higher in patients with psoriasis in the presence of autoimmune thyroiditis. It has been hypothesized that CXCL10 could be a good marker to monitor the activity or progression of psoriasis. Efforts have been made to modulate or inhibit the CXCR3/CXCL10 axis in psoriasis to modify the course of the disease.

CXCL10 in psoriasis / Ferrari, Silvia Martina; Ruffilli, Ilaria; Colaci, Michele; Antonelli, Alessandro; Ferri, Clodoveo; Fallahi, Poupak. - In: ADVANCES IN MEDICAL SCIENCES. - ISSN 1896-1126. - 60:2(2015), pp. 349-354. [10.1016/j.advms.2015.07.011]

CXCL10 in psoriasis

FERRARI, Silvia Martina;COLACI, Michele;FERRI, Clodoveo;
2015

Abstract

Chemokine (C-X-C motif) ligand (CXCL)10 is involved in the pathogenesis of psoriasis. It has been demonstrated that chemokine (C-X-C motif) receptors (CXCR)3 and CXCL10 were detected in keratinocytes and the dermal infiltrate obtained from active psoriatic plaques and that successful treatment of active plaques decreased the expression of CXCL10. Elevated CXCL10 serum levels have been shown in patients with psoriasis, with a type 1 T helper cells immune predominance at the beginning of the disease, while a decline of this chemokine has been evidenced later, in long lasting psoriasis. Circulating CXCL10 is significantly higher in patients with psoriasis in the presence of autoimmune thyroiditis. It has been hypothesized that CXCL10 could be a good marker to monitor the activity or progression of psoriasis. Efforts have been made to modulate or inhibit the CXCR3/CXCL10 axis in psoriasis to modify the course of the disease.
12-ago-2015
60
2
349
354
CXCL10 in psoriasis / Ferrari, Silvia Martina; Ruffilli, Ilaria; Colaci, Michele; Antonelli, Alessandro; Ferri, Clodoveo; Fallahi, Poupak. - In: ADVANCES IN MEDICAL SCIENCES. - ISSN 1896-1126. - 60:2(2015), pp. 349-354. [10.1016/j.advms.2015.07.011]
Ferrari, Silvia Martina; Ruffilli, Ilaria; Colaci, Michele; Antonelli, Alessandro; Ferri, Clodoveo; Fallahi, Poupak
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1074403
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