In the present work the degradation profile of an anticancer peptide in different biological matrixes like DMEM (Dulbecco’s Modified Eagle Medium) and cell lysates by LC Chip Q-TOF was shown. Subsequently, an LC-MS/MS method for the quantitative analysis of LR in cell lysates was developed and fully validated.
EVALUATION OF LR STABILITY BY LC CHIP Q-TOF AND QUANTITATIVE DETERMINATION OF LR PEPTIDE CELL PENETRATION BY LC-MS/MS / Cazzato, ADDOLORATA STEFANIA; Cannazza, Giuseppe; Ponterini, Glauco; Marraccini, Chiara; Pirondi, Silvia; Genovese, Filippo; Costi, Maria Paola. - In: LA CHIMICA E L'INDUSTRIA. - ISSN 0009-4315. - STAMPA. - 2, Marzo-Aprile:(2014), pp. 41-42.
EVALUATION OF LR STABILITY BY LC CHIP Q-TOF AND QUANTITATIVE DETERMINATION OF LR PEPTIDE CELL PENETRATION BY LC-MS/MS
CAZZATO, ADDOLORATA STEFANIA;CANNAZZA, Giuseppe;PONTERINI, Glauco;MARRACCINI, CHIARA;GENOVESE, Filippo;COSTI, Maria Paola
2014
Abstract
In the present work the degradation profile of an anticancer peptide in different biological matrixes like DMEM (Dulbecco’s Modified Eagle Medium) and cell lysates by LC Chip Q-TOF was shown. Subsequently, an LC-MS/MS method for the quantitative analysis of LR in cell lysates was developed and fully validated.
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