The brain suprapontine mechanisms associated with human cataplexy have not been clarified. Animal data suggest that the amygdala and the ventromedial prefrontal cortex are key regions in promoting emotion-induced cataplectic attacks. Twenty-one drug-naive children/adolescent (13 males, mean age 11 years) with recent onset of narcolepsy type 1 (NT1) were studied with fMRI while viewing funny videos using a "naturalistic" paradigm. fMRI data were acquired synchronously with EEG, mylohyoid muscle activity, and the video of the patient's face. Whole-brain hemodynamic correlates of (1) a sign of fun and amusement (laughter) and of (2) cataplexy were analyzed and compared. Correlations analyses between these contrasts and disease-related variables and behavioral findings were performed.

The Brain Correlates of Laugh and Cataplexy in Childhood Narcolepsy / Meletti, Stefano; Vaudano, Anna Elisabetta; Pizza, Fabio; Ruggieri, Andrea; Vandi, Stefano; Teggi, Alberto; Franceschini, Christian; Benuzzi, Francesca; Nichelli, Paolo Frigio; Plazzi, Giuseppe. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - STAMPA. - 35:33(2015), pp. 11583-11594. [10.1523/JNEUROSCI.0840-15.2015]

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