Medication-overuse headache (MOH) is a chronic disorder that results from the overuse of analgesics drugs, triptans or other acute headache compounds. Although the exact mechanisms underlying MOH remain still unknown, several studies suggest that it may be associated with development of "central sensitization", which may cause cutaneous allodynia (CA). Furthermore, the epidemiology of drug-induced disorders suggests that medication overuse could lead to nephrotoxicity. The aim of this work was to confirm and validate the results obtained from previous proteomics studies, in which we analyzed the urinary proteome of MOH patients in comparison with healthy non-abusers individuals.

Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache / Bellei, Elisa; Monari, Emanuela; Bergamini, Stefania; Cuoghi, Aurora; Tomasi, Aldo; Guerzoni, Simona; Ciccarese, Michela; Pini, Luigi Alberto. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - ELETTRONICO. - 16:(2015), pp. 1-9. [10.1186/s10194-015-0559-8]

Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache

BELLEI, Elisa;MONARI, Emanuela;BERGAMINI, Stefania;CUOGHI, Aurora;TOMASI, Aldo;GUERZONI, Simona;CICCARESE, Michela;PINI, Luigi Alberto
2015

Abstract

Medication-overuse headache (MOH) is a chronic disorder that results from the overuse of analgesics drugs, triptans or other acute headache compounds. Although the exact mechanisms underlying MOH remain still unknown, several studies suggest that it may be associated with development of "central sensitization", which may cause cutaneous allodynia (CA). Furthermore, the epidemiology of drug-induced disorders suggests that medication overuse could lead to nephrotoxicity. The aim of this work was to confirm and validate the results obtained from previous proteomics studies, in which we analyzed the urinary proteome of MOH patients in comparison with healthy non-abusers individuals.
15-ago-2015
16
1
9
Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache / Bellei, Elisa; Monari, Emanuela; Bergamini, Stefania; Cuoghi, Aurora; Tomasi, Aldo; Guerzoni, Simona; Ciccarese, Michela; Pini, Luigi Alberto. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - ELETTRONICO. - 16:(2015), pp. 1-9. [10.1186/s10194-015-0559-8]
Bellei, Elisa; Monari, Emanuela; Bergamini, Stefania; Cuoghi, Aurora; Tomasi, Aldo; Guerzoni, Simona; Ciccarese, Michela; Pini, Luigi Alberto
File in questo prodotto:
File Dimensione Formato  
validation_JHP.pdf

accesso aperto

Descrizione: versione finale articolo
Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 726.44 kB
Formato Adobe PDF
726.44 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1072330
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 8
social impact