TAGLIAZUCCHI, LORENZO
TAGLIAZUCCHI, LORENZO
Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze
A dual-Omics approach to identify the modulated proteins/genes in THP-1 cells infected with different drug resistant L. infantum clinical isolates.
2023 Tagliazucchi, Lorenzo; Perea-Martinez, Ana; Fiorini, Greta; Ignacio Manzano, José; García-Hernández, Raquel; Genovese, Filippo; Pinetti, Diego; Gamarro, Francisco; Costi, Maria Paola
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties
2022 Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Moschella, MARIA GAETANA; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Advances in the set-up of a fluorescence- anisotropy assay for the search of novel inhibitors of the tead-4 complexes
2019 Romito, Filippo; Tagliazucchi, Lorenzo; Pozzi, Cecilia; Mangani, Stefano; Lopresti, Ludovica; Ponterini, Glauco; Costi, Maria Paola
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective
2023 Pozzi, Cecilia; Vanet, Anne; Francesconi, Valeria; Tagliazucchi, Lorenzo; Tassone, Giusy; Venturelli, Alberto; Spyrakis, Francesca; Mazzorana, Marco; Costi, Maria P; Tonelli, Michele
Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA
2023 Malpezzi, Giulia; Viader, Xvaier; Zaltron, Annamaria; Neri, Benedetta; di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro
Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme
2021 Tagliazucchi, Lorenzo; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Characterization and Valorization of the Agricultural Waste Obtained from Lavandula Steam Distillation for Its Reuse in the Food and Pharmaceutical Fields
2022 Truzzi, Eleonora; Chaouch, Mohamed Aymen; Rossi, Gaia; Tagliazucchi, Lorenzo; Bertelli, Davide; Benvenuti, Stefania
Coupling a microwave-assisted process with HPLC-ELSD for the extraction, purification and analysis of bioactive policosanols from beeswax
2021 Venturelli, Alberto; Brighenti, Virginia; Tagliazucchi, Lorenzo; Costi, Maria Paola; Pellati, Federica
Current Treatments to Control African Trypanosomiasis and One Health Perspective
2022 Venturelli, Alberto; Tagliazucchi, Lorenzo; Lima, Clara; Venuti, Federica; Malpezzi, Giulia; Magoulas, George E.; Santarem, Nuno; Calogeropoulou, Theodora; Cordeiro-da-Silva, Anabela; Costi, Maria Paola
design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer
2023 Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Elisi, GIAN MARCO; Mor, Marco; Moschella, MARIA GAETANA; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth
2021 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Venturelli, Alberto; D'Arca, Domenico; Marverti, Gaetano; Cecconi, Ciro; Ponterini, Glauco; Costi, Maria Paola
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
2022 Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; MH Salo-Ahen, Outi; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, MARIA GAETANA; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; CORDEIRO DA SILVA, Anabela; Giovannetti, Elisa; J Peters, Godefridus; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; M Stroud, Robert; C Wade, Rebecca; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma
2023 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Aiello, Daniele; Zappaterra, Dana; Elisi, GIAN MARCO; Venturelli, Alberto; Moschella, MARIA GAETANA; D'Arca, Domenico; Marverti, Gaetano; Lopresti, Ludovica; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Ponterini, Glauco; Costi, Maria Paola
Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems
2022 Moschella, Mg; Marverti, G; Cassanelli, Valentina; Venuti, Federica; Tagliazucchi, L; Costi, Mp; D’Arca., D
Development of guanidino-containing benzimidazoles as novel folate enzymes inhibitors for the treatment of Human African Trypanosomiasis
2021 Rizzo, Marco; Francesconi, Valeria; Cichero, Elena; Schenone, Silvia; Tagliazucchi, Lorenzo; Cordeiro da Silva, Anabela; Costi, Maria Paola; Tonelli, Michele
Discovery of guanidino-containing benzimidazoles as novel antifolates for Trypanosomiasis
2022 Francesconi, Valeria; Rizzo, Marco; Tagliazucchi, Lorenzo; Pozzi, Cecilia; CORDEIRO DA SILVA, Anabela; Venuti, Federica; Konchie, Claude; Costi, Maria Paola; Michele, Tonelli
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase
2021 Tassone, Giusy; Landi, Giacomo; Linciano, Pasquale; Francesconi, Valeria; Tonelli, Michele; Tagliazucchi, Lorenzo; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia
Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption
2022 Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Costi, Maria Paola
Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA
2023 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro
EXPLOITING THE OPTICAL TWEEZER, A SINGLE MOLECULE TECHNOLOGY, TO REVEAL THYMIDYLATE SYNTHASE INTERACTIONS WITH ITS CONSENSUS mRNA
2023 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria; Costi, Maria Paola; D’Arcae, Domenico; Cecconi, Ciro
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A dual-Omics approach to identify the modulated proteins/genes in THP-1 cells infected with different drug resistant L. infantum clinical isolates. | 1-gen-2023 | Tagliazucchi, Lorenzo; Perea-Martinez, Ana; Fiorini, Greta; Ignacio Manzano, José; García-Hernández, Raquel; Genovese, Filippo; Pinetti, Diego; Gamarro, Francisco; Costi, Maria Paola | |
| A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties | 1-gen-2022 | Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Moschella, MARIA GAETANA; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Advances in the set-up of a fluorescence- anisotropy assay for the search of novel inhibitors of the tead-4 complexes | 1-gen-2019 | Romito, Filippo; Tagliazucchi, Lorenzo; Pozzi, Cecilia; Mangani, Stefano; Lopresti, Ludovica; Ponterini, Glauco; Costi, Maria Paola | |
| Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective | 1-gen-2023 | Pozzi, Cecilia; Vanet, Anne; Francesconi, Valeria; Tagliazucchi, Lorenzo; Tassone, Giusy; Venturelli, Alberto; Spyrakis, Francesca; Mazzorana, Marco; Costi, Maria P; Tonelli, Michele | |
| Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA | 1-gen-2023 | Malpezzi, Giulia; Viader, Xvaier; Zaltron, Annamaria; Neri, Benedetta; di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro | |
| Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme | 1-gen-2021 | Tagliazucchi, Lorenzo; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Characterization and Valorization of the Agricultural Waste Obtained from Lavandula Steam Distillation for Its Reuse in the Food and Pharmaceutical Fields | 1-gen-2022 | Truzzi, Eleonora; Chaouch, Mohamed Aymen; Rossi, Gaia; Tagliazucchi, Lorenzo; Bertelli, Davide; Benvenuti, Stefania | |
| Coupling a microwave-assisted process with HPLC-ELSD for the extraction, purification and analysis of bioactive policosanols from beeswax | 1-gen-2021 | Venturelli, Alberto; Brighenti, Virginia; Tagliazucchi, Lorenzo; Costi, Maria Paola; Pellati, Federica | |
| Current Treatments to Control African Trypanosomiasis and One Health Perspective | 1-gen-2022 | Venturelli, Alberto; Tagliazucchi, Lorenzo; Lima, Clara; Venuti, Federica; Malpezzi, Giulia; Magoulas, George E.; Santarem, Nuno; Calogeropoulou, Theodora; Cordeiro-da-Silva, Anabela; Costi, Maria Paola | |
| design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer | 1-gen-2023 | Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Elisi, GIAN MARCO; Mor, Marco; Moschella, MARIA GAETANA; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth | 1-gen-2021 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Venturelli, Alberto; D'Arca, Domenico; Marverti, Gaetano; Cecconi, Ciro; Ponterini, Glauco; Costi, Maria Paola | |
| Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth | 1-gen-2022 | Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; MH Salo-Ahen, Outi; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, MARIA GAETANA; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; CORDEIRO DA SILVA, Anabela; Giovannetti, Elisa; J Peters, Godefridus; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; M Stroud, Robert; C Wade, Rebecca; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma | 1-gen-2023 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Aiello, Daniele; Zappaterra, Dana; Elisi, GIAN MARCO; Venturelli, Alberto; Moschella, MARIA GAETANA; D'Arca, Domenico; Marverti, Gaetano; Lopresti, Ludovica; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Ponterini, Glauco; Costi, Maria Paola | |
| Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems | 1-gen-2022 | Moschella, Mg; Marverti, G; Cassanelli, Valentina; Venuti, Federica; Tagliazucchi, L; Costi, Mp; D’Arca., D | |
| Development of guanidino-containing benzimidazoles as novel folate enzymes inhibitors for the treatment of Human African Trypanosomiasis | 1-gen-2021 | Rizzo, Marco; Francesconi, Valeria; Cichero, Elena; Schenone, Silvia; Tagliazucchi, Lorenzo; Cordeiro da Silva, Anabela; Costi, Maria Paola; Tonelli, Michele | |
| Discovery of guanidino-containing benzimidazoles as novel antifolates for Trypanosomiasis | 1-gen-2022 | Francesconi, Valeria; Rizzo, Marco; Tagliazucchi, Lorenzo; Pozzi, Cecilia; CORDEIRO DA SILVA, Anabela; Venuti, Federica; Konchie, Claude; Costi, Maria Paola; Michele, Tonelli | |
| Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase | 1-gen-2021 | Tassone, Giusy; Landi, Giacomo; Linciano, Pasquale; Francesconi, Valeria; Tonelli, Michele; Tagliazucchi, Lorenzo; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia | |
| Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption | 1-gen-2022 | Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Costi, Maria Paola | |
| Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA | 1-gen-2023 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro | |
| EXPLOITING THE OPTICAL TWEEZER, A SINGLE MOLECULE TECHNOLOGY, TO REVEAL THYMIDYLATE SYNTHASE INTERACTIONS WITH ITS CONSENSUS mRNA | 1-gen-2023 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria; Costi, Maria Paola; D’Arcae, Domenico; Cecconi, Ciro |