A delivery system for the concurrent administration of drugs was prepared inserting a conventional hydrochlorothiazide tablet in the hole of a perforated matrix of captopril coated on all the surfaces except the hole surface. The influence of both the hole diameter and the drug/polymer ratio on the release process was evaluated. According to the system design, hydrochlorothiazide was promptly liberated from the tablet inserted in the hole, whereas captopril was gradually released following a linear release profile. No significant differences were pointed out between the release behavior of both drugs in de-ionized water and in simulated gastrointestinal fluids.
A DELIVERY SYSTEM FOR THE CONCURRENT ADMINISTRATION OF HYDROCHLOROTHIAZIDE AND CAPTOPRIL / Vandelli, Maria Angela; Forni, Flavio; Bernabei, Mt. - In: STP PHARMA SCIENCES. - ISSN 1157-1489. - STAMPA. - 5:(1995), pp. 357-360.
A DELIVERY SYSTEM FOR THE CONCURRENT ADMINISTRATION OF HYDROCHLOROTHIAZIDE AND CAPTOPRIL
VANDELLI, Maria Angela;FORNI, Flavio;
1995
Abstract
A delivery system for the concurrent administration of drugs was prepared inserting a conventional hydrochlorothiazide tablet in the hole of a perforated matrix of captopril coated on all the surfaces except the hole surface. The influence of both the hole diameter and the drug/polymer ratio on the release process was evaluated. According to the system design, hydrochlorothiazide was promptly liberated from the tablet inserted in the hole, whereas captopril was gradually released following a linear release profile. No significant differences were pointed out between the release behavior of both drugs in de-ionized water and in simulated gastrointestinal fluids.
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