tAnimal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect malereproductive function. The aim of the present study was to evaluate if male reproductive function wasassociated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmen-tal exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markersof DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine.Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 expo-sure and markers of male semen quality or reproductive hormones. In the largest study to date wedemonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristicsor reproductive hormones, indicating that male reproductive function is not affected by the exposurelevel of these compounds in fertile European or Arctic populations.
Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine / Gunnar, Toft; Virissa, Lenters; Roel, Vermeulen; Dick, Heederik; Cathrine, Thomsen; Georg, Becher; Aleksander, Giwercman; Davide, Bizzaro; Manicardi, Gian Carlo; Marcello, Spanò; Lars, Rylander; Henning S., Pedersen; Paweł, Strucinski; Valentyna, Zviezdai; Jens Peter, Bonde. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - STAMPA. - 43:(2014), pp. 1-7. [10.1016/j.reprotox.2013.10.002]
Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine
MANICARDI, Gian Carlo;
2014
Abstract
tAnimal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect malereproductive function. The aim of the present study was to evaluate if male reproductive function wasassociated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmen-tal exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markersof DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine.Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 expo-sure and markers of male semen quality or reproductive hormones. In the largest study to date wedemonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristicsor reproductive hormones, indicating that male reproductive function is not affected by the exposurelevel of these compounds in fertile European or Arctic populations.
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