We performed a molecular study aimed at identifying a gene expression profile (GEP) signature predictive of attainment of at least near complete response (CR) to thalidomide-dexamethasone (TD) as induction regimen in preparation for double autologous stem cell transplantation in 112 younger patients with newly diagnosed multiple myeloma. A GEP supervised analysis was performed on a training set of 32 patients, allowing to identify 157 probe sets differentially expressed in patients with CR versus those failing CR to TD. We then generated an eight-gene GEP signature whose performance was subsequently validated in a training set of 80 patients. A correct prediction of response to TD was found in 71 % of the cases analyzed. The eight genes were downregulated in patients who achieved CR to TD. Comparisons between post-autotransplantation outcomes of the 44 non-CR-predicted patients and of the 36 CR-predicted patients showed that this latter subgroup had a statistically significant benefit in terms of higher rate of CR after autotransplant(s) and longer time to progression, event-free survival, and overall survival. These results can be an important first step to identify at diagnosis those patients who will respond more favourably to a particular treatment strategy.
|Data di pubblicazione:||2013|
|Titolo:||Correlation between eight-gene expression profiling and response to therapy of newly diagnosed multiple myeloma patients treated with thalidomide-dexamethasone incorporated into double autologous transplantation.|
|Autori:||Terragna, C; Renzulli, M; Remondini, D; Tagliafico, E; Di Raimondo, F; Patriarca, F; Martinelli, G; Roncaglia, E; Masini, L; Tosi, P; Zamagni, E; Tacchetti, P; Ledda, A; Brioli, A; Angelucci, E; Testoni, N; Marzocchi, G; Galieni, P; Gozzetti, A; Martello, M; Dico, F; Mancuso, K; Cavo, M|
|Autori interni:||TAGLIAFICO, Enrico|
|Digital Object Identifier (DOI):||10.1007/s00277-013-1757-6|
|Rivista:||ANNALS OF HEMATOLOGY|
|Appare nelle tipologie:||Articolo su rivista|
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