We describe a potentiometric sensor based on Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) for “in vitro” detection of dopamine. The sensing element of this device resides at the Au gate–aqueous solution interface by means of a self-assembled monolayer (SAM) composed by cysteamine and 4-formylphenyl boronic acid. The covalent and selective adsorption of dopamine induces a surface dipole potential which shifts the electrode work function and modulates the double layer capacitance. As a result, our device is capable to detect dopamine up to pico-molar concentration showing higher sensitivity with respect to other approaches. For this reason the interface engineering of our EGOFET gate is a promising route for diagnostic applications.

Organic field-effect transistor for label-free dopamine sensing / Casalini, S; Leonardi, F; Cramer, T; Biscarini, Fabio. - In: ORGANIC ELECTRONICS. - ISSN 1566-1199. - 14:1(2013), pp. 156-163. [10.1016/j.orgel.2012.10.027]

Organic field-effect transistor for label-free dopamine sensing

BISCARINI, FABIO
2013

Abstract

We describe a potentiometric sensor based on Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) for “in vitro” detection of dopamine. The sensing element of this device resides at the Au gate–aqueous solution interface by means of a self-assembled monolayer (SAM) composed by cysteamine and 4-formylphenyl boronic acid. The covalent and selective adsorption of dopamine induces a surface dipole potential which shifts the electrode work function and modulates the double layer capacitance. As a result, our device is capable to detect dopamine up to pico-molar concentration showing higher sensitivity with respect to other approaches. For this reason the interface engineering of our EGOFET gate is a promising route for diagnostic applications.
2013
14
1
156
163
Organic field-effect transistor for label-free dopamine sensing / Casalini, S; Leonardi, F; Cramer, T; Biscarini, Fabio. - In: ORGANIC ELECTRONICS. - ISSN 1566-1199. - 14:1(2013), pp. 156-163. [10.1016/j.orgel.2012.10.027]
Casalini, S; Leonardi, F; Cramer, T; Biscarini, Fabio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/963156
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