Soft connective tissue calcification is not a passive process, but the consequence of metabolic changes of local mesenchymal cells that, depending on both genetic and environmental factors, alter the balance between pro- and anti-calcifying pathways. While the role of smooth muscle cells and pericytes in ectopic calcifications has been widely investigated, the involvement of fibroblasts is still elusive. Fibroblasts isolated from the dermis of pseudoxanthoma elasticum (PXE) patients and of patients exhibiting PXE-like clinical and histopathological findings offer an attractive model to investigate the mechanisms leading to the precipitation of mineral deposits within elastic fibers and to explore the influence of the genetic background and of the extracellular environment on fibroblast-associated calcifications, thus improving the knowledge on the role of mesenchymal cells on pathologic mineralization

Fibroblast involvement in soft connective tissue calcification / Ronchetti, I.; Boraldi, Federica; Annovi, Giulia; Cianciulli, P.; Quaglino, Daniela. - In: FRONTIERS IN GENETICS. - ISSN 1664-8021. - ELETTRONICO. - 4:(2013), pp. 17-32. [10.3389/fgene.2013.00022]

Fibroblast involvement in soft connective tissue calcification

BORALDI, Federica;ANNOVI, Giulia;QUAGLINO, Daniela
2013

Abstract

Soft connective tissue calcification is not a passive process, but the consequence of metabolic changes of local mesenchymal cells that, depending on both genetic and environmental factors, alter the balance between pro- and anti-calcifying pathways. While the role of smooth muscle cells and pericytes in ectopic calcifications has been widely investigated, the involvement of fibroblasts is still elusive. Fibroblasts isolated from the dermis of pseudoxanthoma elasticum (PXE) patients and of patients exhibiting PXE-like clinical and histopathological findings offer an attractive model to investigate the mechanisms leading to the precipitation of mineral deposits within elastic fibers and to explore the influence of the genetic background and of the extracellular environment on fibroblast-associated calcifications, thus improving the knowledge on the role of mesenchymal cells on pathologic mineralization
2013
4
17
32
Fibroblast involvement in soft connective tissue calcification / Ronchetti, I.; Boraldi, Federica; Annovi, Giulia; Cianciulli, P.; Quaglino, Daniela. - In: FRONTIERS IN GENETICS. - ISSN 1664-8021. - ELETTRONICO. - 4:(2013), pp. 17-32. [10.3389/fgene.2013.00022]
Ronchetti, I.; Boraldi, Federica; Annovi, Giulia; Cianciulli, P.; Quaglino, Daniela
File in questo prodotto:
File Dimensione Formato  
2013 Fibroblasts and calcifications - Frontiers.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 12.23 MB
Formato Adobe PDF
12.23 MB Adobe PDF Visualizza/Apri
fgene-04-00022.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 1.34 MB
Formato Adobe PDF
1.34 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/953094
Citazioni
  • ???jsp.display-item.citation.pmc??? 26
  • Scopus 54
  • ???jsp.display-item.citation.isi??? ND
social impact