BACKGROUND: The role of [(18)F] fluorodeoxyglucose (FDG)-positron emission tomography (PET) in follicular lymphoma (FL) staging is not yet determined. PATIENTS AND METHODS: The aim of the present study was to investigate the role of PET in the initial staging of FL patients enrolled in the FOLL05-phase-III trial that compared first-line regimens (R-CVP, R-CHOP and R-FM). Patients should have undergone conventional staging and have available PET baseline to be included. RESULTS: A total of 142 patients were analysed. PET identified a higher number of nodal areas in 32% (46 of 142) of patients and more extranodal (EN) sites than computed tomography (CT) scan. Also, the Follicular Lymphoma International Prognostic Index (FLIPI) score increased in 18% (26 of 142) and decreased in 6% (9 of 142) of patients. Overall, the impact of PET on modifying the stage was highest in patients with limited stage. Actually, 62% (15 of 24) of cases with limited disease were upstaged with PET. CONCLUSIONS: The inclusion of PET among staging procedures makes the evaluation of patients with FL more accurate and has the potential to modify therapy decision and prognosis in a moderate proportion of patients. Further prospective clinical trials on FL should incorporate PET at different moments, and the therapeutic criteria to start therapy should be re-visited in the views of this new tool.

The use of FDG-PET in the initial staging of 142 patients with follicular lymphoma: a retrospective study from the FOLL05 randomized trial of the Fondazione Italiana Linfomi / Luminari, Stefano; Biasoli, I.; Arcaini, L.; Versari, A.; Rusconi, C.; Merli, F.; Spina, M.; Ferreri, A. J.; Zinzani, P. L.; Gallamini, A.; Mastronardi, S.; Boccomini, C.; Gaidano, G.; D'Arco, A. M.; Di Raimondo, F.; Carella, A. M.; Santoro, A.; Musto, P.; Federico, Massimo. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 24 (8):(2013), pp. 2108-2112. [10.1093/annonc/mdt137]

The use of FDG-PET in the initial staging of 142 patients with follicular lymphoma: a retrospective study from the FOLL05 randomized trial of the Fondazione Italiana Linfomi

LUMINARI, Stefano;FEDERICO, Massimo
2013

Abstract

BACKGROUND: The role of [(18)F] fluorodeoxyglucose (FDG)-positron emission tomography (PET) in follicular lymphoma (FL) staging is not yet determined. PATIENTS AND METHODS: The aim of the present study was to investigate the role of PET in the initial staging of FL patients enrolled in the FOLL05-phase-III trial that compared first-line regimens (R-CVP, R-CHOP and R-FM). Patients should have undergone conventional staging and have available PET baseline to be included. RESULTS: A total of 142 patients were analysed. PET identified a higher number of nodal areas in 32% (46 of 142) of patients and more extranodal (EN) sites than computed tomography (CT) scan. Also, the Follicular Lymphoma International Prognostic Index (FLIPI) score increased in 18% (26 of 142) and decreased in 6% (9 of 142) of patients. Overall, the impact of PET on modifying the stage was highest in patients with limited stage. Actually, 62% (15 of 24) of cases with limited disease were upstaged with PET. CONCLUSIONS: The inclusion of PET among staging procedures makes the evaluation of patients with FL more accurate and has the potential to modify therapy decision and prognosis in a moderate proportion of patients. Further prospective clinical trials on FL should incorporate PET at different moments, and the therapeutic criteria to start therapy should be re-visited in the views of this new tool.
24 (8)
2108
2112
The use of FDG-PET in the initial staging of 142 patients with follicular lymphoma: a retrospective study from the FOLL05 randomized trial of the Fondazione Italiana Linfomi / Luminari, Stefano; Biasoli, I.; Arcaini, L.; Versari, A.; Rusconi, C.; Merli, F.; Spina, M.; Ferreri, A. J.; Zinzani, P. L.; Gallamini, A.; Mastronardi, S.; Boccomini, C.; Gaidano, G.; D'Arco, A. M.; Di Raimondo, F.; Carella, A. M.; Santoro, A.; Musto, P.; Federico, Massimo. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 24 (8):(2013), pp. 2108-2112. [10.1093/annonc/mdt137]
Luminari, Stefano; Biasoli, I.; Arcaini, L.; Versari, A.; Rusconi, C.; Merli, F.; Spina, M.; Ferreri, A. J.; Zinzani, P. L.; Gallamini, A.; Mastronardi, S.; Boccomini, C.; Gaidano, G.; D'Arco, A. M.; Di Raimondo, F.; Carella, A. M.; Santoro, A.; Musto, P.; Federico, Massimo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/934892
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