AIMS: Several studies confirmed the growing rate of Type 1 diabetes mellitus in childhood coinciding with increasing diagnosis of viral infections. A study investigating the incidence of Type 1 diabetes during 1996-1997 showed a higher notification of viral infections in the Pavia District. The aim was to confirm these results. METHODS: This study evaluated the relationship between new cases of Type 1 diabetes and those of measles, mumps and rubella in 1996-2001, analysing data of newly-diagnosed Type 1 diabetes children, aged 0-14 years and enrolled into the RIDI (Italian Insulin-dependent Diabetes Registry) during the same years. Measles, rubella and mumps rates were calculated using as denominator the estimated 'population at risk', represented by the number of 0- to 14 year-old subjects who did not undergo the MMR (measles, mumps and rubella) vaccination. In order to investigate the association between Type 1 diabetes incidence and measles, rubella and mumps respectively, Spearman's rank correlation was used. RESULTS: The analysis of the whole Registries data did not at first show any statistical significance between age-standardized Type 1 diabetes incidence density and estimated rates of measles, mumps and rubella notifications. Excluding data from Sardinia Registry, a significant association was observed between Type 1 diabetes incidence and mumps (P = 0.034) and rubella (P = 0.014), respectively, while there was no statistical significance between the incidence of measles cases and diabetes rates (P = 0.269). CONCLUSIONS: According to our findings, mumps and rubella viral infections are associated with the onset of Type 1 diabetes. The statistical significance observed after exclusion of the Sardinian data suggests that other environmental factors may operate over populations with different genetic susceptibility.
Type 1 diabetes and measles, mumps and rubella childhood infections within the Italian Insulin-dependent Diabetes Registry / Ramondetti, F; Sacco, S; Comelli, M; Bruno, G; Falorni, A; Iannilli, A; D'Annunzio, G; Iafusco, D; Songini, M; Toni, S; Cherubini, V; Carle, F; Cerutti, F; Novelli, G; Bianchi, L; Piffer, S; Lorini, R; Minuto, N; Roncarolo, F; Tenconi, T; Predieri, Barbara; Reali, Mf; Medici, A; Biagioni, M; Gesuita, R; Santeusanio, F; De Giorgi, G; Visalli, N; Bizzarri, C; Chiarelli, F; Tumini, S; Prisco, F; Confett, S; Frongia, P; Marinaro, A. M.. - In: DIABETIC MEDICINE. - ISSN 0742-3071. - STAMPA. - 29(6):(2012), pp. 761-766. [10.1111/j.1464-5491.2011.03529.x.]