A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA),was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.
Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis / Luna, T; Mazzolla, R; Romano, G; Blasi, Elisabetta. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 41:(1997), pp. 706-708.
Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis
BLASI, Elisabetta
1997
Abstract
A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA),was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.
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