Genes expressed in the somatopleuric mesoderm, the embryonic domain giving rise to the vertebrate pelvis, appear important for pelvic girdle formation. Among such genes, Pbx family members and Emx2 were found to genetically interact in hindlimb and pectoral girdle formation. Here, we generated compound mutant embryos carrying combinations of mutated alleles for Pbx1, Pbx2, and Pbx3, as well as Pbx1 and Emx2, to examine potential genetic interactions during pelvic development. Indeed, Pbx genes share overlapping functions and Pbx1 and Emx2 genetically interact in pelvic formation. We show that, in compound Pbx1;Pbx2 and Pbx1;Emx2 mutants, pelvic mesenchymal condensation is markedly perturbed, indicative of an upstream control by these homeoproteins. We establish that expression of Tbx15, Prrx1, and Pax1, among other genes involved in the specification and development of select pelvic structures, is altered in our compound mutants. Lastly, we identify potential Pbx1-Emx2-regulated enhancers for Tbx15, Prrx1, and Pax1, using bioinformatics analyses.
Control of pelvic girdle development by genes of the Pbx family and Emx2 / Capellini, Td; Handschuh, K; Quintana, L; Ferretti, E; Di Giacomo, G; Fantini, Sebastian; Vaccari, G; Clarke, Sl; Wenger, Am; Bejerano, G; Sharpe, J; Zappavigna, Vincenzo; Selleri, L.. - In: DEVELOPMENTAL DYNAMICS. - ISSN 1058-8388. - STAMPA. - 240(2011), pp. 1173-1189.
Data di pubblicazione: | 2011 |
Titolo: | Control of pelvic girdle development by genes of the Pbx family and Emx2. |
Autore/i: | Capellini, Td; Handschuh, K; Quintana, L; Ferretti, E; Di Giacomo, G; Fantini, Sebastian; Vaccari, G; Clarke, Sl; Wenger, Am; Bejerano, G; Sharpe, J; Zappavigna, Vincenzo; Selleri, L. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/dvdy.22617 |
Rivista: | |
Volume: | 240 |
Pagina iniziale: | 1173 |
Pagina finale: | 1189 |
Codice identificativo ISI: | WOS:000289942300023 |
Codice identificativo Scopus: | 2-s2.0-79955045629 |
Codice identificativo Pubmed: | 21455939 |
Citazione: | Control of pelvic girdle development by genes of the Pbx family and Emx2 / Capellini, Td; Handschuh, K; Quintana, L; Ferretti, E; Di Giacomo, G; Fantini, Sebastian; Vaccari, G; Clarke, Sl; Wenger, Am; Bejerano, G; Sharpe, J; Zappavigna, Vincenzo; Selleri, L.. - In: DEVELOPMENTAL DYNAMICS. - ISSN 1058-8388. - STAMPA. - 240(2011), pp. 1173-1189. |
Tipologia | Articolo su rivista |
File in questo prodotto:

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris