After primary infection, human herpesvirus-6 (HHV-6) persists in latent form and can be reactivated in immunocompromised subjects. A longitudinal study of HHV-6 infection was carried out in two HIV-1 seropositive patients to provide in vivo evidence of HHV-6 reactivation. Concomitant with a significant rise of anti-HHV-6 IgG detected by IFA, a transient increase of HHV-6 viral load was shown in PBLs by PCR. During HHV-6 reactivation it was also identified either cell-free HHV-6 by PCR in plasma or IgM antibody titers. HHV-6 reactivation was followed by a temporary decrease in CD4+ count and by a progressive dramatic loss of CD4+ during the following 18 months. HHV-6 strain characterization by PCR demonstrated that first patient (MM) initially showed the B variant, followed by reactivation and persistence of the A variant, while in the second (SG) only the A variant was detected. The evidence of HHV-6 reactivation suggests its involvement in immunologic damage underlying the disease.
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|Anno di pubblicazione:||1997|
|Titolo:||Human herpesvirus-6 reactivation in a longitudinal study of two HIV-1 infected patients|
|Autori:||Iuliano R; Trovato R; Lico S; Luppi M; Forastieri G; Barsanti LA; Pizzigallo AM; Mecocci L; Barozzi P; Torelli G; Mazzotta F; CeccheriniNelli L|
|Autori interni:||LUPPI, Mario |
|Rivista:||JOURNAL OF MEDICAL VIROLOGY|
|Appare nelle tipologie:||Articolo su rivista|
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