Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. e percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specic direct association with melanoma risk. o other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These fndings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.

Serum fatty acids and risk of cutaneous melanoma: a population-based case-control study / Vinceti, Marco; Malagoli, Carlotta; Iacuzio, Laura; Catherine M., Crespi; Sabina, Sieri; Vittorio, Krogh; Marmiroli, Sandra; Pellacani, Giovanni; Elisabetta, Venturelli. - In: DERMATOLOGY RESEARCH AND PRACTICE. - ISSN 1687-6113. - ELETTRONICO. - 2013:(2013), pp. 1-7. [10.1155/2013/659394]

Serum fatty acids and risk of cutaneous melanoma: a population-based case-control study

VINCETI, Marco;MALAGOLI, Carlotta;IACUZIO, LAURA;MARMIROLI, Sandra;PELLACANI, Giovanni;
2013

Abstract

Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. e percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specic direct association with melanoma risk. o other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These fndings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.
2013
1
7
Serum fatty acids and risk of cutaneous melanoma: a population-based case-control study / Vinceti, Marco; Malagoli, Carlotta; Iacuzio, Laura; Catherine M., Crespi; Sabina, Sieri; Vittorio, Krogh; Marmiroli, Sandra; Pellacani, Giovanni; Elisabetta, Venturelli. - In: DERMATOLOGY RESEARCH AND PRACTICE. - ISSN 1687-6113. - ELETTRONICO. - 2013:(2013), pp. 1-7. [10.1155/2013/659394]
Vinceti, Marco; Malagoli, Carlotta; Iacuzio, Laura; Catherine M., Crespi; Sabina, Sieri; Vittorio, Krogh; Marmiroli, Sandra; Pellacani, Giovanni; Elisabetta, Venturelli
File in questo prodotto:
File Dimensione Formato  
Derm_Res_Pract_2013.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 486.42 kB
Formato Adobe PDF
486.42 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/912289
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 9
  • ???jsp.display-item.citation.isi??? ND
social impact