Background: Pulmonary rehabilitation (PR) has emerged as a recommended standard of care in symptomatic COPD. Objectives: We now studied whether PR may affect cardiovascular response to exercise in these patients. Methods: Twenty-seven patients (9F; age: 69 yrs ± 8) with moderate to severe airflow obstruction admitted to a 9-week PR course performed a pre-to-post evaluation of lung function test and symptom-limited cardiopulmonary exercise test (CPET). Oxygen uptake (VO2), tidal volume (VT), dyspnoea and leg fatigue scores were measured during CPET. Cardiovascular response was assessed by means of oxygen pulse (O2Pulse), the oxygen uptake efficiency slope (OUES) and heart rate recovery at the 1st min (HRR). Results: A significant increase in peak VO2 and in all cardiovascular parameters (p<0.05) was found following PR, as compared to baseline. Leg fatigue (p<0.05), but not dyspnoea was significantly reduced after RP. When assessed at metabolic and ventilatory iso levels (%VCO2max and %VEmax), O2Pulse and VT were significantly higher (p<0.05) at submaximal exercise (75% and 50% of VCO2max and VEmax) after RP, when compared to baseline. VT percent changes at 75% VCO2max and 75% VEmax after RP significantly correlated with corresponding changes in O2Pulse (p<0.01). Conclusions: In COPD patients, a PR training program improved the cardiovascular response during exercise at submaximal exercise independent on the external workload. This change was associated with an enhanced ventilatory function during exercise.
Pulmonary Rehabilitation Improves Cardiovascular Response to Exercise in COPD / S., Ramponi; P., Tzani; M., Aiello; E., Marangio; Clini, Enrico; A., Chetta. - In: RESPIRATION. - ISSN 0025-7931. - ELETTRONICO. - 86(2013), pp. 17-24.
|Data di pubblicazione:||2013|
|Titolo:||Pulmonary Rehabilitation Improves Cardiovascular Response to Exercise in COPD.|
|Autore/i:||S., Ramponi; P., Tzani; M., Aiello; E., Marangio; Clini, Enrico; A., Chetta|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000348726|
|Codice identificativo ISI:||WOS:000324653000005|
|Codice identificativo Scopus:||2-s2.0-84880571876|
|Codice identificativo Pubmed:||23711671|
|Citazione:||Pulmonary Rehabilitation Improves Cardiovascular Response to Exercise in COPD / S., Ramponi; P., Tzani; M., Aiello; E., Marangio; Clini, Enrico; A., Chetta. - In: RESPIRATION. - ISSN 0025-7931. - ELETTRONICO. - 86(2013), pp. 17-24.|
|Tipologia||Articolo su rivista|
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