Rationale Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30–50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung. Objectives We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung. Findings The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin. Conclusions Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB.

Prognostic role of clusterin in resected adenocarcinomas of the lung / Panico, Francesca; Casali, C; Rossi, Giulio; Rizzi, F; Morandi, Uliano; Bettuzzi, Sara; Davalli, Pierpaola; Corbetta, Lorenzo; Storelli, Es; Corti, Arnaldo; Fabbri, Leonardo; Astancolle, Serenella; Luppi, Fabrizio. - In: LUNG CANCER. - ISSN 0169-5002. - STAMPA. - 79:3(2013), pp. 294-299. [10.1016/j.lungcan.2012.11.024]

Prognostic role of clusterin in resected adenocarcinomas of the lung.

PANICO, Francesca;ROSSI, Giulio;MORANDI, Uliano;DAVALLI, Pierpaola;CORTI, Arnaldo;FABBRI, Leonardo;ASTANCOLLE, Serenella;LUPPI, Fabrizio
2013

Abstract

Rationale Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30–50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung. Objectives We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung. Findings The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin. Conclusions Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB.
2013
79
3
294
299
Prognostic role of clusterin in resected adenocarcinomas of the lung / Panico, Francesca; Casali, C; Rossi, Giulio; Rizzi, F; Morandi, Uliano; Bettuzzi, Sara; Davalli, Pierpaola; Corbetta, Lorenzo; Storelli, Es; Corti, Arnaldo; Fabbri, Leonardo; Astancolle, Serenella; Luppi, Fabrizio. - In: LUNG CANCER. - ISSN 0169-5002. - STAMPA. - 79:3(2013), pp. 294-299. [10.1016/j.lungcan.2012.11.024]
Panico, Francesca; Casali, C; Rossi, Giulio; Rizzi, F; Morandi, Uliano; Bettuzzi, Sara; Davalli, Pierpaola; Corbetta, Lorenzo; Storelli, Es; Corti, Ar...espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/904089
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 17
social impact