An HPLC-CSP method has been developed for the separation of enantiomers of verapamil and gallopamil using the improved version of the alpha(1)-acid glycoprotein, chiral stationary phase as selector with a volatile mobile phase. The results of the investigation provide the conditions which allow direct coupling to a mass spectrometer. In addition, the simultaneous enantioseparation of both the enantiomeric pairs of verapamil and gallopamil was achieved.
Resolution of the enantiomers of verapamil and gallopamil by chiral liquid chromatography mass spectrometry / Rustichelli, Cecilia; Ferioli, Valeria; Gamberini, G.. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - ELETTRONICO. - 44:(1997), pp. 477-483.
Resolution of the enantiomers of verapamil and gallopamil by chiral liquid chromatography mass spectrometry
RUSTICHELLI, Cecilia;FERIOLI, Valeria;
1997
Abstract
An HPLC-CSP method has been developed for the separation of enantiomers of verapamil and gallopamil using the improved version of the alpha(1)-acid glycoprotein, chiral stationary phase as selector with a volatile mobile phase. The results of the investigation provide the conditions which allow direct coupling to a mass spectrometer. In addition, the simultaneous enantioseparation of both the enantiomeric pairs of verapamil and gallopamil was achieved.
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