Using a spectrofluorimetric procedure, we found that the plasma membrane from hemocytes of two freshwater snails, Planorbarius corneus and Viviparus ater, shows neutral endopeptidase-24.11 (NEP)-like activity. Moreover, the addition of ACTH(1-24) to the hemolymph provokes an increase in NEP-like activity. This increased NEP-like activity is blocked by phosphoramidon, a potent inhibitor of mammalian NEP. These findings suggest that this peptidase ha been well conserved in the course of evolution and plays an important role in immune-neuroendocrine mechanisms.
Neutral endopeptidase-24.11 (NEP)-like activity in molluscan hemocytes / Ottaviani, Enzo; E., Caselgrandi. - In: PEPTIDES. - ISSN 0196-9781. - STAMPA. - 18:(1997), pp. 1107-1110.
Neutral endopeptidase-24.11 (NEP)-like activity in molluscan hemocytes
OTTAVIANI, Enzo;
1997-01-01
Abstract
Using a spectrofluorimetric procedure, we found that the plasma membrane from hemocytes of two freshwater snails, Planorbarius corneus and Viviparus ater, shows neutral endopeptidase-24.11 (NEP)-like activity. Moreover, the addition of ACTH(1-24) to the hemolymph provokes an increase in NEP-like activity. This increased NEP-like activity is blocked by phosphoramidon, a potent inhibitor of mammalian NEP. These findings suggest that this peptidase ha been well conserved in the course of evolution and plays an important role in immune-neuroendocrine mechanisms.
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