Mesoporous bioactive glass scaffolds (MBG-Scs), based on 80% SiO 2-15% CaO-5% P 2O 5 (in mol.%) mesoporous sol-gel glasses substituted with Ce 2O 3, Ga 2O 3 (both 0.2% or 1.0%) and ZnO (0.4% or 2.0%), were synthesized by combination of evaporation-induced self-assembly and rapid prototyping techniques. Cerium, gallium and zinc trace elements were selected because of their inherent beneficial biological properties. Fabricated scaffolds were characterized and compared with unsubstituted scaffold (B-Sc). All of them contained well interconnected ultralarge pores (pores >400 μm) ideal for vascular ingrowth and proliferation of cells. Macropores of size 100-400 μm were present inside the scaffolds. In addition, low-angle X-ray diffraction showed that B-Sc and scaffolds with substituent contents up to 0.4% exhibited ordered mesoporosity useful for hosting molecules with biological activity. The textural properties of B-Sc were a surface area of 398 m 2 g -1, a pore diameter of 4.3 nm and a pore volume of 0.43 cm 3 g -1. A slight decrease in surface area and pore volume was observed upon substitution with no distinct effect on pore diameter. In addition, all the MBG-Scs except 2.0% ZnO-Sc showed quite quick in vitro bioactive response. Hence, the present study is a positive addition to ongoing research into preparing bone tissue engineering scaffolds from bioceramics containing elements of therapeutic significance.

Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses / Shruti, Shruti; A. J., Salinas; Lusvardi, Gigliola; Malavasi, Gianluca; Menabue, Ledi; M., Vallet Regi. - In: ACTA BIOMATERIALIA. - ISSN 1742-7061. - ELETTRONICO. - 9:1(2013), pp. 4836-4844. [10.1016/j.actbio.2012.09.024]

Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses

SHRUTI, SHRUTI;LUSVARDI, Gigliola;MALAVASI, Gianluca;MENABUE, Ledi;
2013

Abstract

Mesoporous bioactive glass scaffolds (MBG-Scs), based on 80% SiO 2-15% CaO-5% P 2O 5 (in mol.%) mesoporous sol-gel glasses substituted with Ce 2O 3, Ga 2O 3 (both 0.2% or 1.0%) and ZnO (0.4% or 2.0%), were synthesized by combination of evaporation-induced self-assembly and rapid prototyping techniques. Cerium, gallium and zinc trace elements were selected because of their inherent beneficial biological properties. Fabricated scaffolds were characterized and compared with unsubstituted scaffold (B-Sc). All of them contained well interconnected ultralarge pores (pores >400 μm) ideal for vascular ingrowth and proliferation of cells. Macropores of size 100-400 μm were present inside the scaffolds. In addition, low-angle X-ray diffraction showed that B-Sc and scaffolds with substituent contents up to 0.4% exhibited ordered mesoporosity useful for hosting molecules with biological activity. The textural properties of B-Sc were a surface area of 398 m 2 g -1, a pore diameter of 4.3 nm and a pore volume of 0.43 cm 3 g -1. A slight decrease in surface area and pore volume was observed upon substitution with no distinct effect on pore diameter. In addition, all the MBG-Scs except 2.0% ZnO-Sc showed quite quick in vitro bioactive response. Hence, the present study is a positive addition to ongoing research into preparing bone tissue engineering scaffolds from bioceramics containing elements of therapeutic significance.
2013
9
1
4836
4844
Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses / Shruti, Shruti; A. J., Salinas; Lusvardi, Gigliola; Malavasi, Gianluca; Menabue, Ledi; M., Vallet Regi. - In: ACTA BIOMATERIALIA. - ISSN 1742-7061. - ELETTRONICO. - 9:1(2013), pp. 4836-4844. [10.1016/j.actbio.2012.09.024]
Shruti, Shruti; A. J., Salinas; Lusvardi, Gigliola; Malavasi, Gianluca; Menabue, Ledi; M., Vallet Regi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/873889
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