EnglishMesoporous bioactive glass scaffolds (MBG-Scs), based on 80% SiO 2-15% CaO-5% P 2O 5 (in mol.%) mesoporous sol-gel glasses substituted with Ce 2O 3, Ga 2O 3 (both 0.2% or 1.0%) and ZnO (0.4% or 2.0%), were synthesized by combination of evaporation-induced self-assembly and rapid prototyping techniques. Cerium, gallium and zinc trace elements were selected because of their inherent beneficial biological properties. Fabricated scaffolds were characterized and compared with unsubstituted scaffold (B-Sc). All of them contained well interconnected ultralarge pores (pores >400 μm) ideal for vascular ingrowth and proliferation of cells. Macropores of size 100-400 μm were present inside the scaffolds. In addition, low-angle X-ray diffraction showed that B-Sc and scaffolds with substituent contents up to 0.4% exhibited ordered mesoporosity useful for hosting molecules with biological activity. The textural properties of B-Sc were a surface area of 398 m 2 g -1, a pore diameter of 4.3 nm and a pore volume of 0.43 cm 3 g -1. A slight decrease in surface area and pore volume was observed upon substitution with no distinct effect on pore diameter. In addition, all the MBG-Scs except 2.0% ZnO-Sc showed quite quick in vitro bioactive response. Hence, the present study is a positive addition to ongoing research into preparing bone tissue engineering scaffolds from bioceramics containing elements of therapeutic significance.
Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses / Shruti, Shruti; A. J., Salinas; Lusvardi, Gigliola; Malavasi, Gianluca; Menabue, Ledi; M., Vallet Regi. - In: ACTA BIOMATERIALIA. - ISSN 1742-7061. - ELETTRONICO. - 9(2013), pp. 4836-4844. [10.1016/j.actbio.2012.09.024]
| Data di pubblicazione: | 2013 | |
| Titolo: | Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses | |
| Autore/i: | Shruti, Shruti; A. J., Salinas; Lusvardi, Gigliola; Malavasi, Gianluca; Menabue, Ledi; M., Vallet Regi | |
| Autore/i UNIMORE: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.actbio.2012.09.024 | |
| Rivista: | ||
| Volume: | 9 | |
| Pagina iniziale: | 4836 | |
| Pagina finale: | 4844 | |
| Codice identificativo ISI: | WOS:000313376900040 | |
| Codice identificativo Scopus: | 2-s2.0-84870235162 | |
| Codice identificativo Pubmed: | 23026489 | |
| Citazione: | Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses / Shruti, Shruti; A. J., Salinas; Lusvardi, Gigliola; Malavasi, Gianluca; Menabue, Ledi; M., Vallet Regi. - In: ACTA BIOMATERIALIA. - ISSN 1742-7061. - ELETTRONICO. - 9(2013), pp. 4836-4844. [10.1016/j.actbio.2012.09.024] | |
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