In this chapter we summarize some aspects of the structure-functional relationship of the α 1a and α 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the α 1a and α 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action / S., Cotecchia; O., Rossier; Fanelli, Francesca; A., Leonardi; DE BENEDETTI, Pier Giuseppe. - STAMPA. - 31:(2000), pp. 173-179. (Intervento presentato al convegno N/A tenutosi a N/A nel N/A) [10.1016/S0165-7208(00)80015-X].
The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action
FANELLI, Francesca;DE BENEDETTI, Pier Giuseppe
2000
Abstract
In this chapter we summarize some aspects of the structure-functional relationship of the α 1a and α 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the α 1a and α 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
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