The Aging Skeleton: Differences Between HIV-Infected Patients and the Uninfected Aging Population

Osteoporosis is defined as a reduction in bone mass and disruption of bone architecture, resulting in reduced bone strength and increased fracture risk. Fractures show a steep age-related increase and have a major impact on the health of elderly. The objective of this review is to describe the aging skeleton as a paradigm of the biological aging process affecting patients with HIV infection. We will focus on the comparison between HIV infected and uninfected individuals with regards to risk factors for bone disease, fractures events and the association between bone diseases and other age related conditions. We will critically discuss the assessment for fracture risk in HIV infected patients and some management issue regarding this condition.