Muscle biopsy was examined in 20 children with cerebral palsy, using immunohistochemical methods for marker of denervation neural cell adhesion molecules (N-CAM) in addition to standard techniques. Histological and histochemical study showed mild myopathic changes, type 1 predominance, and type 1 and type 2 hypotrophy, in accord with previous observations. Immunohistochemical study showed N-CAM expression in most biopsies (15/20), usually in scattered fibers, whereas in four patients aged less than 6 years it was expressed in grouped fibers. Our study supports the hypothesis of motor unit remodeling as a consequence of spasticity, especially in early phases of the disease.

Immunohistochemical study of muscle biopsy in children with cerebral palsy / A., Marbini; Ferrari, Adriano; G., Cioni; M. F., Bellanova; C., Fusco; F., Gemignani. - In: BRAIN & DEVELOPMENT. - ISSN 0387-7604. - STAMPA. - 24(2002), pp. 63-66.

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