Muscle biopsy was examined in 20 children with cerebral palsy, using immunohistochemical methods for marker of denervation neural cell adhesion molecules (N-CAM) in addition to standard techniques. Histological and histochemical study showed mild myopathic changes, type 1 predominance, and type 1 and type 2 hypotrophy, in accord with previous observations. Immunohistochemical study showed N-CAM expression in most biopsies (15/20), usually in scattered fibers, whereas in four patients aged less than 6 years it was expressed in grouped fibers. Our study supports the hypothesis of motor unit remodeling as a consequence of spasticity, especially in early phases of the disease.
Immunohistochemical study of muscle biopsy in children with cerebral palsy / A., Marbini; Ferrari, Adriano; G., Cioni; M. F., Bellanova; C., Fusco; F., Gemignani. - In: BRAIN & DEVELOPMENT. - ISSN 0387-7604. - STAMPA. - 24(2002), pp. 63-66.
Data di pubblicazione: | 2002 | |
Titolo: | Immunohistochemical study of muscle biopsy in children with cerebral palsy | |
Autore/i: | A., Marbini; Ferrari, Adriano; G., Cioni; M. F., Bellanova; C., Fusco; F., Gemignani | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 24 | |
Pagina iniziale: | 63 | |
Pagina finale: | 66 | |
Codice identificativo ISI: | WOS:000174903800001 | |
Codice identificativo Scopus: | 2-s2.0-0036124866 | |
Codice identificativo Pubmed: | 11891093 | |
Citazione: | Immunohistochemical study of muscle biopsy in children with cerebral palsy / A., Marbini; Ferrari, Adriano; G., Cioni; M. F., Bellanova; C., Fusco; F., Gemignani. - In: BRAIN & DEVELOPMENT. - ISSN 0387-7604. - STAMPA. - 24(2002), pp. 63-66. | |
Tipologia | Articolo su rivista |
File in questo prodotto:
Pubblicazioni consigliate

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris