Driven by co-evolutionary forces, viruses have refined a wide arsenal of strategies to interfere with the host defences. On one hand, viruses can block/retard programmed cell death in infected cells, thereby suppressing one of the most ancient mechanisms against viral dissemination. On the other hand, multiple viral factors can efficiently trigger the death of infected cells and uninfected cells from the immune system, which favours viral spreading and prevents/limits an active antiviral response, respectively. Moreover, several viruses are able to inhibit the molecular machinery that drives the translocation of calreticulin to the surface of dying cells. Thereby, viruses block the exposure of an engulfment signal that is required for the efficient uptake of dying cells by dendritic cells and for the induction of the immune response. In this review, we discuss a variety of mechanisms by which viruses interfere with the cell death machinery and, in particular, by which they subvert immunogenic cell death.

Viral strategies for the evasion of immunogenic cell death / Galluzzi, Lorenzo; Kepp, O; Morselli, Eugenia; Vitale, I; Senovilla, L; Pinti, Marcello; Zitvogel, L; Kroemer, G.. - In: JOURNAL OF INTERNAL MEDICINE. - ISSN 0954-6820. - STAMPA. - 267:5(2010), pp. 526-542. [10.1111/j.1365-2796.2010.02223.x]

Viral strategies for the evasion of immunogenic cell death

GALLUZZI, Lorenzo;MORSELLI, EUGENIA;PINTI, Marcello;
2010

Abstract

Driven by co-evolutionary forces, viruses have refined a wide arsenal of strategies to interfere with the host defences. On one hand, viruses can block/retard programmed cell death in infected cells, thereby suppressing one of the most ancient mechanisms against viral dissemination. On the other hand, multiple viral factors can efficiently trigger the death of infected cells and uninfected cells from the immune system, which favours viral spreading and prevents/limits an active antiviral response, respectively. Moreover, several viruses are able to inhibit the molecular machinery that drives the translocation of calreticulin to the surface of dying cells. Thereby, viruses block the exposure of an engulfment signal that is required for the efficient uptake of dying cells by dendritic cells and for the induction of the immune response. In this review, we discuss a variety of mechanisms by which viruses interfere with the cell death machinery and, in particular, by which they subvert immunogenic cell death.
2010
267
526
542
Galluzzi, Lorenzo; Kepp, O; Morselli, Eugenia; Vitale, I; Senovilla, L; Pinti, Marcello; Zitvogel, L; Kroemer, G.
Viral strategies for the evasion of immunogenic cell death / Galluzzi, Lorenzo; Kepp, O; Morselli, Eugenia; Vitale, I; Senovilla, L; Pinti, Marcello; Zitvogel, L; Kroemer, G.. - In: JOURNAL OF INTERNAL MEDICINE. - ISSN 0954-6820. - STAMPA. - 267:5(2010), pp. 526-542. [10.1111/j.1365-2796.2010.02223.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/858695
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