Tenofovir accelerates bone mass loss of the lumbar spine in the first years of menopause in HIV infected women.

Previous studies haveshown that HIV-infected postmenopausal women have higer rates of bone loss than HIV negative women. No studies so far have analyzed the slope of bone loss across the menopausal transition period. We hypothesized that in HIV infected women BMD decreases in the postmenopausal period and Tenofovir exposure may contribute to this impairment. The aim of the study was to identify predictors of BMD in HIV infected women entering menopause and to evaluate the pre- and post- menopausal BMD change.