We examined the efficacy and effect of HAART in HIV-1-infected men confronted with assisted fertilization procedures. We showed that HAART did not always reduce the HIV-1-RNA level in blood and semen compartments, and that a significant upward shift in mitochondrial DNA was observed in spermatozoa from a HAART-treated patient group compared with spermatozoa from HAART-untreated or HIV-1-uninfected groups (P < 0.001). These findings emphasize the negative role of HAART, but not of HIV-1 infection, in determining semen alterations.
Dynamics of HIV viral load in blood and semen of patients under HAART: impact of therapy in assisted reproduction procedures / LA SALA, Giovanni Battista; Pilotti, E; Nicoli, A; Pinelli, S; Villani, Mt; Ronzi, P; Zendri, E; Re, Mc; Magnani, G; Casoli, C.. - In: AIDS. - ISSN 0269-9370. - ELETTRONICO. - 21:(2007), pp. 377-379. [10.1097/QAD.0b013e328012ccfb]
Dynamics of HIV viral load in blood and semen of patients under HAART: impact of therapy in assisted reproduction procedures.
LA SALA, Giovanni Battista;
2007
Abstract
We examined the efficacy and effect of HAART in HIV-1-infected men confronted with assisted fertilization procedures. We showed that HAART did not always reduce the HIV-1-RNA level in blood and semen compartments, and that a significant upward shift in mitochondrial DNA was observed in spermatozoa from a HAART-treated patient group compared with spermatozoa from HAART-untreated or HIV-1-uninfected groups (P < 0.001). These findings emphasize the negative role of HAART, but not of HIV-1 infection, in determining semen alterations.
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