Suitable programming models and associated supporting infrastructures are required to deal with large software systems dived in complex and dynamic network environments. Here, with the aid of a case study scenario, we discuss the inadequacies of current approaches in dealing with such scenarios. Then we sketch the key characteristics of TOTA (Tuples On The Air), as a novel proposal to deal with the above inadequacies. TOTA relies on tuple-based information to be spatially diffused in the network and to be exploited by application agents so as to achieve context-awareness and consequently to effectively coordinate with each other despite the network dynamics.