Recent clinical and toxicological studies have investigated the mineralcorticoid-like and hypertensive effects of liquorice, and we therefore set out to identify the active component responsible for these effects. We conducted a 30-day comparative analysis of glycyrrhizin and 18 beta-glycyrrhetinic acid and found that the latter causes significant variations both in systolic blood pressure and in the excretion in the urine of Ca++. The effects were fully reversible on suspension of treatment.
Glycyrrhizin and 18 beta-glycyrrhetinic acid: a comparative study of the pharmacological effects induced in the rat after prolonged oral treatment / Rossi, T; Vampa, G; Benvenuti, Stefania; Pini, Luigi Alberto; Galatulas, I; Bossa, R; Castelli, M; Ruberto, Ai; Baggio, G.. - In: IN VIVO. - ISSN 0258-851X. - STAMPA. - 8:(1994), pp. 317-320.