The use of biomarkers to assess cancer risk is based on the model of cancer as a multistep process; such markers are assumed to reflect an early stage in this process. A valid biomarker of risk must therefore show differential expression in normal and high-risk subjects, as well as quantitative correlation with the stage of carcinogenesis. It should also be easy to detect in small tissue specimens and responsive to modulation by chemopreventive agents. Cell proliferation is one of the most widely investigated markers of cancer risk. Case-control studies have shown that epithelial cell proliferation parameters, assessed in rectal mucosal biopsies by means of in vitro autoradiographic or immunohistochemical techniques, can discriminate between populations with normal and high risks for colon cancer. However, we recently reviewed rectal biopsies from 152 subjects (43 controls, 84 with adenomas, 25 resected for colon cancer) processed for in vitro 3H-thymidine autoradiography, and attempted to correlate various proliferative parameters with clinical and pathological variables by means of multiple regression analysis.

Modulating effect of omega-3 fatty acids on the proliferative pattern of human colorectal mucosa / Anti, M; Marra, G; Armelao, F; Percesepe, Antonio; Gentiloni, N.. - STAMPA. - 400:(1997), pp. 605-610. (Intervento presentato al convegno 3rd International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury tenutosi a GEORGETOWN UNIV CONF CTR, WASHINGTON, D.C. nel OCT 13-16, 1993).

Modulating effect of omega-3 fatty acids on the proliferative pattern of human colorectal mucosa.

PERCESEPE, Antonio;
1997

Abstract

The use of biomarkers to assess cancer risk is based on the model of cancer as a multistep process; such markers are assumed to reflect an early stage in this process. A valid biomarker of risk must therefore show differential expression in normal and high-risk subjects, as well as quantitative correlation with the stage of carcinogenesis. It should also be easy to detect in small tissue specimens and responsive to modulation by chemopreventive agents. Cell proliferation is one of the most widely investigated markers of cancer risk. Case-control studies have shown that epithelial cell proliferation parameters, assessed in rectal mucosal biopsies by means of in vitro autoradiographic or immunohistochemical techniques, can discriminate between populations with normal and high risks for colon cancer. However, we recently reviewed rectal biopsies from 152 subjects (43 controls, 84 with adenomas, 25 resected for colon cancer) processed for in vitro 3H-thymidine autoradiography, and attempted to correlate various proliferative parameters with clinical and pathological variables by means of multiple regression analysis.
1997
3rd International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury
GEORGETOWN UNIV CONF CTR, WASHINGTON, D.C.
OCT 13-16, 1993
400
605
610
Anti, M; Marra, G; Armelao, F; Percesepe, Antonio; Gentiloni, N.
Modulating effect of omega-3 fatty acids on the proliferative pattern of human colorectal mucosa / Anti, M; Marra, G; Armelao, F; Percesepe, Antonio; Gentiloni, N.. - STAMPA. - 400:(1997), pp. 605-610. (Intervento presentato al convegno 3rd International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury tenutosi a GEORGETOWN UNIV CONF CTR, WASHINGTON, D.C. nel OCT 13-16, 1993).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/845691
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