Since two centuries the use of digitalis glycosides for treatment of congestive heart failure has received conflicting acceptance by clinicians. We studied a group of94 old-aged patients with various degrees of chronic heat failure receiving chronically two types of digitalis(digoxin or B-metyl-digoxin) to evaluate compliance, adverse reaction and clinical picture. The study confirmed that both drugs were able to give a good compliance, with therapeutic plasma levels, without signs of accumulation. In conclusion treatment of elderly patients with low doses of digitalis without clinical signs of heart insufficiency or referring this event in the past , o showing sub-therapeutic serum digoxin levels is a practice not to be stressed
Serum levels and clinical response to digoxin in congestive heart failure in the elderly / Pini, Luigi Alberto; Magnavacchi, P; Ricci, S.. - In: CLINICAL PHARMACOLOGY. - ISSN 0937-0978. - STAMPA. - 3:(1990), pp. 101-106. (Intervento presentato al convegno International stellite Symp to the 4th world conference of clinical Pharmacol and Ther. tenutosi a Wuppertal nel 28-30 July 1989).
Serum levels and clinical response to digoxin in congestive heart failure in the elderly
PINI, Luigi Alberto;
1990
Abstract
Since two centuries the use of digitalis glycosides for treatment of congestive heart failure has received conflicting acceptance by clinicians. We studied a group of94 old-aged patients with various degrees of chronic heat failure receiving chronically two types of digitalis(digoxin or B-metyl-digoxin) to evaluate compliance, adverse reaction and clinical picture. The study confirmed that both drugs were able to give a good compliance, with therapeutic plasma levels, without signs of accumulation. In conclusion treatment of elderly patients with low doses of digitalis without clinical signs of heart insufficiency or referring this event in the past , o showing sub-therapeutic serum digoxin levels is a practice not to be stressed
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