A single oral dose of glibenclamide (2.5 mg) was given to eight healthy volunteers in a randomized cross-over study after a standardized fasting and breakfast (374 kcal), with or without a concomitant intake of 10 ml of antacid suspension. Serum glibenclamide levels were determined by means of a specific radioimmunoassay method. The areas under the blood concentration-time curves (AUC0-infinity), with or without antacid, were 408.17 +/- 168.25 and 307.9 +/- 84.13 ng/ml (p less than 0.05), respectively. The peak concentrations of 96.88 +/- 49.9 and 66.19 +/- 32.35 ng/ml/h (p less than 0.05) with or without antacid, were reached in 4.13 and 3.81 h, respectively. Values of tmax, Vd and t1/2 were not affected by the presence of the antacid. A 33% increase in bioavailability of glibenclamide emerged, as seen from the respective AUC values, but no clinically remarkable effect was observed in the subjects.

Influence of antacids on the bioavailability of glibenclamide / Zuccaro, P; Pacifici, R; Pichini, S; Avico, U; Federzoni, G; Pini, Luigi Alberto; Sternieri, E.. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - STAMPA. - 15:(1989), pp. 165-169.

Influence of antacids on the bioavailability of glibenclamide.

PINI, Luigi Alberto;
1989

Abstract

A single oral dose of glibenclamide (2.5 mg) was given to eight healthy volunteers in a randomized cross-over study after a standardized fasting and breakfast (374 kcal), with or without a concomitant intake of 10 ml of antacid suspension. Serum glibenclamide levels were determined by means of a specific radioimmunoassay method. The areas under the blood concentration-time curves (AUC0-infinity), with or without antacid, were 408.17 +/- 168.25 and 307.9 +/- 84.13 ng/ml (p less than 0.05), respectively. The peak concentrations of 96.88 +/- 49.9 and 66.19 +/- 32.35 ng/ml/h (p less than 0.05) with or without antacid, were reached in 4.13 and 3.81 h, respectively. Values of tmax, Vd and t1/2 were not affected by the presence of the antacid. A 33% increase in bioavailability of glibenclamide emerged, as seen from the respective AUC values, but no clinically remarkable effect was observed in the subjects.
15
165
169
Influence of antacids on the bioavailability of glibenclamide / Zuccaro, P; Pacifici, R; Pichini, S; Avico, U; Federzoni, G; Pini, Luigi Alberto; Sternieri, E.. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - STAMPA. - 15:(1989), pp. 165-169.
Zuccaro, P; Pacifici, R; Pichini, S; Avico, U; Federzoni, G; Pini, Luigi Alberto; Sternieri, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/840093
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