We have assessed plasma GSH in patients using paracetamol daily. In these patients a significant lower plasma GSH concentration was found with respect to controls. After the i.v. administration of GSH free plasma cysteine was 12 fold higher than in basal condition and all the pattern of plasma thiol groups was modified. This work suggests that the possible protective effect of GSH administration is due to the availability of plasma thiol compounds that enter the cell rather than GSH itself.
The decrease in plasma thiol groups in daily headache paracetamol abuser patients as possible factor of pain maintenance / Trenti, T; Bertolotti, Marco; Ferrari, Anna; Pini, Luigi Alberto; Sternieri, E.. - In: CEPHALALGIA. - ISSN 0333-1024. - STAMPA. - 13, suppl. 13:(1993), pp. 241-241. (Intervento presentato al convegno VIth Congress of the International Headache Society, Paris, France, 26-29 August 1993 tenutosi a Paris, France nel 26-29 August 1993).
The decrease in plasma thiol groups in daily headache paracetamol abuser patients as possible factor of pain maintenance
BERTOLOTTI, Marco;FERRARI, Anna;PINI, Luigi Alberto;
1993
Abstract
We have assessed plasma GSH in patients using paracetamol daily. In these patients a significant lower plasma GSH concentration was found with respect to controls. After the i.v. administration of GSH free plasma cysteine was 12 fold higher than in basal condition and all the pattern of plasma thiol groups was modified. This work suggests that the possible protective effect of GSH administration is due to the availability of plasma thiol compounds that enter the cell rather than GSH itself.
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