The use of flunarizine in the preventive treatment of headaches and migraine is now widely done. Taking into account that the main and more frequent side effects of this treatment are weight gain and increase of appetite, with a typical carbohydrates craving, we studied the influence of a prolonged treatment of flunarizine on glucose, C- peptide and insulin metabolism in headache sufferers. All these substances were studied before and after treatment and we did not find significant differences after the treatment. So we could conclude that this drug even if increases appetite , does not interfere with glucose metabolism and it is possible to hypothesize that the carbohydrate craving could be related to a facilitate income of glucose into the cell.

INFLUENCE OF PROLONGED THERAPY WITH FLUNARIZINE ON GLUCOSE, INSULIN AND C-PEPTIDE METABOLISM / Pini, Luigi Alberto; Ferrari, Anna; E., Sternieri. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - STAMPA. - 20(1988), pp. 633-634.

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