Pharmacokinetics of NSAIDS is relevant both for therapeutic and side effects especially with regard in "A" type of side effects and in their incidence. It is observed that NSAIDs reach high concentrations in body compartments in which cause therapeutic or unwanted effects, and therefore it is important to know pharmacokinetics of these drugs. The four phases of pharmacokinetics are explained, and the differences within different drugs are reported. It is important to note that from there differences it should be possible avoid known side effects or minimize it by using an appropriate drug dispensation regimen. Finally the investigation of these pharmacokinetic parameters could lead to develop better drugs as well to avoid accidents with new compounds extensively employed in clinical practice.
PHARMACOKINETICS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS / E., Sternieri; Pini, Luigi Alberto. - STAMPA. - (1988), pp. 347-352. (Intervento presentato al convegno SYMP AT THE 3RD MEETING OF THE INTERNATIONAL HEADACHE SOC : PAIN AND REPRODUCTION tenutosi a Modena Italy nel 20-22 spt 1987).
PHARMACOKINETICS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS
PINI, Luigi Alberto
1988
Abstract
Pharmacokinetics of NSAIDS is relevant both for therapeutic and side effects especially with regard in "A" type of side effects and in their incidence. It is observed that NSAIDs reach high concentrations in body compartments in which cause therapeutic or unwanted effects, and therefore it is important to know pharmacokinetics of these drugs. The four phases of pharmacokinetics are explained, and the differences within different drugs are reported. It is important to note that from there differences it should be possible avoid known side effects or minimize it by using an appropriate drug dispensation regimen. Finally the investigation of these pharmacokinetic parameters could lead to develop better drugs as well to avoid accidents with new compounds extensively employed in clinical practice.Pubblicazioni consigliate
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