This book is a collection of 30 chapters of widely varying subject matter—the unifying theme being that these chapters deal with depression, headache, or both. Sections include the following: neurochemistry of 5-hydroxytryptamine pathways, with four excellent chapters on this subject and review of findings as they relate to headache, depression, and pain; chronic headache and mood disorders, four primarily clinical chapters with a brief, interesting review of pain threshold studies; periodicity of affective and headache disorders, with chapters on seasonal cycles found in depression, menstrual cycles in mood and headache, and effects of different treatments; drugs affecting the serotonergic system (seven chapters of widely varying quality) with three review articles, one (by Sicuteri) giving a summary of his overall formulation of central pain systems, another summarizing data on serotonin and depression, and three subsequent studies briefly reporting results on specific pharmacologic agents

Pharmacological outline of chronic headache patients: overlap between depressive and nociceptive symptomatology / Sternieri, Emilio; Guaraldi, Gp; Mazzi, Fausto; Venuta, Marco; Orlandi, Emanuele; Trenti, T; Bertolotti, Marco; Ferrari, Anna; Pini, Luigi Alberto. - STAMPA. - (1991), pp. 79-86.

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