The various opioid peptides thus far isolated and characterized are derived from three different bio- synthetìc precursors (Fig. l). The aminoacid (AA) sequence of these proteins has been determined by recombinant DNA techniques, namely, determining the nucleotide sequence of DNA complementary to the mRNA encoding these precursors. The three precursors are pro-opiomelanocortin (POMC), pre- proenkephalin A, and preproenkephalin B. There are some similarities in the structural organization of these three precursors, suggesting a common evolu- tionary derivation.
Localization and Expression of the Three Opioid Systems / Facchinetti, Fabio; M., D.; Felice, Petraglia; M., D.; A. R., Genazzani; M., D.. - In: SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY. - ISSN 0734-8630. - STAMPA. - 5:2:(1987), pp. 83-83.
Localization and Expression of the Three Opioid Systems
FACCHINETTI, Fabio;
1987
Abstract
The various opioid peptides thus far isolated and characterized are derived from three different bio- synthetìc precursors (Fig. l). The aminoacid (AA) sequence of these proteins has been determined by recombinant DNA techniques, namely, determining the nucleotide sequence of DNA complementary to the mRNA encoding these precursors. The three precursors are pro-opiomelanocortin (POMC), pre- proenkephalin A, and preproenkephalin B. There are some similarities in the structural organization of these three precursors, suggesting a common evolu- tionary derivation.
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